Category: naphthyridine

Woods, Ross M. published the artcileEnantiomeric separation of biaryl atropisomers using cyclofructan based chiral stationary phases, Name: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Journal of Chromatography A (2014), 172-181, database is CAplus and MEDLINE.

Normal phase chiral HPLC methods are presented for the enantiomeric separation of 30 biaryl atropisomers including 18 new compounds recently produced via a novel synthetic approach. Three new cyclofructan based chiral stationary phases were evaluated. Separations were achieved for all but six analytes and the LARIHC CF6-P alone provided 15 baseline separations Effects of polar modifiers and temperature effects also were studied. Apparent thermodn. parameters were determined by van’t Hoff plots. Preparative scale methods were developed and employed resulting in the 1st ever isolation of these novel atropisomers in their pure enantiomeric form. Insights into the mechanism of retention and chiral discrimination are presented.

Journal of Chromatography A published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C6H13N3O2, Name: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shah, Maulin P. published the artcileMicrobial degradation of reactive red by Pseudomonas spp. MPS-2, Synthetic Route of 116-63-2, the publication is Journal of Bioremediation & Biodegradation (2013), 4(6), 1000197/1-1000197/7, database is CAplus.

Azo dyes are a widespread class of poorly biodegradable industrial pollutants. In anaerobic environments, azo bonds are reductively cleaved yielding carcinogenic aromatic amines, many of which are assumed to resist further metabolism by anaerobes bacteria. The latter compounds generally require aerobic conditions for their degradation A reactive group of azo dye called C.I: Reactive Red was found to be degraded using Pseudomonas spp. MPS-79 to α-ketoglutaric acid with transient accumulation of 4-aminobenzenesulfonic acid (sulphanilic acid), 4-amino, 3-hydronaphthalenesulfonic acid and 4-amino, 5-hydronaphthalene 2,7 disulfonic acid as a degradation intermediate in anaerobic facultative batch culture. Color and Total Organic Carbon (TOC) was successfully removed more than 95% and upto 50% resp. There is no significant correlation between pH and oxygen depletion since there is slightly change in pH was observed (pH from 7.21 to 7.25) though the anaerobiosis was found developed throughout the experiment (redox potential from 0.7 to 1.6 mV). The anaerobic metabolism of glucose as co-metabolite also shown to provide the electrons required for the initial reductive cleavage of the azo group. This finding suggest that it is possible to mineralize the azo dye in the environment; thereby, avoiding accumulation of toxic intermediates in the water.

Journal of Bioremediation & Biodegradation published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C14H20BClO2, Synthetic Route of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Anjali published the artcileSynthesis, characterisation, antioxidant and antimicrobial activity of isatin derivatives, Name: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is International Research Journal of Pharmacy (2019), 10(9), 223-230, database is CAplus.

In the present study some novel Schiff bases of isatin I [R = OH, 2-O₂NC₆H₄, 2-Cl-4-O₂NC₆H₃, etc.] were synthesized by condensation of isatin mol. with anilines after performing the mol. docking and ADME prediction. Some new Schiff bases of isatin I were prepared in order to study the antibacterial, antifungal and antioxidant properties. The isatin was synthesized by Sandmeyer method and then its derivatives I were synthesized after obtaining significant results from mol. docking and ADME prediction. The structures of the synthesized compounds I were confirmed by means of IR, ¹H-NMR and elemental anal. Synthesized compounds I were screened for antioxidant activity, among which I [R = 2-Cl-4-O₂NC₆H₃] showed potent activity as antioxidant. Synthesized compounds I showed broad spectrum of antibacterial and antifungal activities.

International Research Journal of Pharmacy published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Name: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kumar, Sunil published the artcileSynthesis, characterization and evaluation for anticonvulsant activity of acetylnaphthalene and substituted acetylenaphthalene derivative of heterocyclic compounds, Synthetic Route of 116-63-2, the publication is Pharma Innovation (2013), 1(11), 90-101, database is CAplus.

A series of acetyl- and acetoxynaphthalenes was prepared by Mannich reaction with secondary amines and CH₂O. In this reaction the Ac group served as he H active compound The novel compounds were tested for anticonvulsant activity using pentylenetetrazole (scPTZ) test. Some of the compounds showed significant anticonvulsant activity.

Pharma Innovation published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Synthetic Route of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sahoo, Anupam published the artcileA Combined Process for the Degradation of Azo-Dyes and Efficient Removal of Aromatic Amines Using Porous Silicon Supported Porous Ruthenium Nanocatalyst, Quality Control of 116-63-2, the publication is ACS Applied Nano Materials (2018), 1(9), 5169-5178, database is CAplus.

Herein, the authors present a facile route for the preparation of porous Si supported porous Ru nanoparticle system (Si@p-RuNP) for efficient removal of azo-based dyes and aromatic amines from wastewater. The synthesized nanoparticles were characterized using different anal. techniques including high-resolution TEM, XPS, field-emission SEM, powder x-ray diffraction, Brunauer-Emmett-Teller anal., etc. The Si@p-RuNP nanocatalytic system exhibits dual catalytic behavior for the reduction of -N=N- bond and oxidation of aromatic amines in aqueous solution The porous nanostructured Si@p-RuNP exhibits excellent degradation efficacy for Congo red dye (44 cycles in 1 h) as compared to its solid analog Si@RuNP (24 cycles in 1 h) in the presence of NaBH₄. Also, the present nanocatalyst mimics the peroxidase-like activity toward oxidation of various aromatic amines to their corresponding polyamines at pH 5.0 in the presence of H₂O₂ as an oxidant. Polyamines being insoluble in H₂O offers a simple and convenient strategy for the elimination of H₂O-soluble aromatic amines. The present process is convenient, efficient, and cost-effective and generates a small amount of solid waste as compared to the existing processes. Thus, the authors envision that the present unique nanocatalyst system can be useful for the removal of toxic amines from effluent toward solving the problem of textile-based industrial wastewater.

ACS Applied Nano Materials published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Mosquera, Angeles published the artcileSynthesis of Axially Chiral 1,1′-Binaphthalenes by Palladium-Catalysed Cross-Coupling Reactions of Triorganoindium Reagents, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is European Journal of Organic Chemistry (2013), 2013(13), 2555-2562, database is CAplus.

1,1′-Binaphthalenes and heterocyclic analogs can be efficiently prepared by palladium-catalyzed cross-coupling reactions between tri(1-naphthyl)indium reagents and 1-halonaphthalenes and haloisoquinolines. The reactions were usually carried out in THF at 80° with a slight excess of the indium reagent (40 mol-%) and a low catalyst loading (4 mol-% Pd) to afford the cross-coupling products in good yields (45-99 %). The method allows the synthesis of sterically hindered 2-substituted and 2,2′-disubstituted 1,1′-binaphthalenes and naphthylisoquinolines. In addition, the coupling reactions can be performed enantioselectively and the best enantiomeric excesses were obtained by using the chiral amino-phosphane ferrocenyl ligand (R,S)-PPFA.

European Journal of Organic Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fang, Jingxian published the artcileGraphene-Oxide-Promoted Direct Dehydrogenative Coupling Reaction of Aromatics, HPLC of Formula: 2960-93-2, the publication is Asian Journal of Organic Chemistry (2018), 7(2), 355-358, database is CAplus.

Graphene oxide, which is a popular 2D carbon material, promoted a direct dehydrogenative coupling reaction of aromatics Homo-coupling and cross-coupling reactions were achieved in good yields in the presence of graphene oxide. This strategy was simple and did not required any other additives, such as acid/base or ligand. The reaction was easily scaled up to gram level.

Asian Journal of Organic Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, HPLC of Formula: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Liu, Bicheng published the artcileA sensitive fluorescent assay for the determination of parathion-methyl using AHNSA probe with MnO₂ nanosheets, Computed Properties of 116-63-2, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2021), 119146, database is CAplus and MEDLINE.

In this paper, a novel fluorescence assay has been constructed for the determination of parathion-Me (PM) by using 4-amino-3-hydroxy-1-naphthalenesulfonic acid (AHNSA) as probe. MnO₂ nanosheets (MnO₂ NS) could quench the fluorescence of AHNSA, while Mn²⁺, the reduction product of MnO₂ NS, has no influence on it, resulting in fluorescence recovery. This is because that MnO₂ NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). In the presence of OPs, the activity of AChE was inhibited, accompanied by the restraint of the redox reaction of MnO₂ NS, therefore the fluorescence of AHNSA was quenched. Under the optimized exptl. conditions, a linear range of PM was determined to be 0.4-40 ng/mL (R² = 0.997) by the proposed method with the limit of detection for 0.18 ng/mL (S/N = 3). The assay was successfully applied to the determination of PM in lake water, which average recoveries were between 86.5% and 114.4%.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sancho, Raquel published the artcileA (4R)-hydroxy-L-proline-derived chiral scaffold and its oligomers as chiral selectors in liquid chromatography chiral stationary phases for enantioseparation, Related Products of naphthyridine, the publication is Journal of Separation Science (2006), 29(6), 905-914, database is CAplus and MEDLINE.

The chromatog. behavior of a poly-L-proline-derivatized chiral stationary phase (CSP) is compared to the corresponding single proline-derived CSP. Structurally diverse racemic test compounds and mobile phases, including normal- and RP conditions, were used. Although the application domain of the poly-L-proline-derived CSP (CSP-3) was considerably restricted, this CSP showed a higher retention and a slightly broader application domain than the monomeric analog (CSP-1) when heptane/2-PrOH was used as mobile phase. The presence of an alc. in the mobile phase was essential for enantioseparation in the poly-L-proline-derived CSP when normal-phase conditions were applied.

Journal of Separation Science published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Verhoog, Stefan published the artcileSilver-Mediated ¹⁸F-Labeling of Aryl-CF₃ and Aryl-CHF₂ with ¹⁸F-Fluoride, Formula: C11H8F2, the publication is Synlett (2016), 27(1), 25-28, database is CAplus.

We report the synthesis of [¹⁸F]arylCF₃ and [¹⁸F]arylCHF₂ derivatives from arylCF₂Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [¹⁸F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce ¹⁸F-incorporation under very mild conditions.

Synlett published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C9H9BrO2, Formula: C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem