Category: naphthyridine

Zhang, Li published the artcileActivated carbon functionalized with 1-amino-2-naphthol-4-sulfonate as a selective solid-phase sorbent for the extraction of gold(III), Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Microchimica Acta (2011), 174(3-4), 391-398, database is CAplus.

A new method for the separation, preconcentration, and determination of gold(III) ion in water samples was developed. It is based on the use of activated carbon that was modified with 1-amino-2-naphthol-4-sulfonate to yield a solid-phase sorbent. The exptl. conditions for adsorption were optimized. Gold(III) can be quant. adsorbed at pH 3, and adsorbed gold(III) can be completely eluted with 2.0 mL of a 2% solution of thiourea in 1 M HCl. The enrichment factor is 200, and the maximum adsorption capacity is 32 mg g^-1. Au was then determined by inductively coupled plasma optical emission spectrometry. The detection limit (3σ) is 0.26 μg L^-1, and the RSD is 3.1% (n = 8). Common potentially interfering ions do not interfere with the adsorption and determination of the analytes. The method displays selectivity, sensitivity and reproducibility, and was successfully applied to the determination of reference materials and water samples.

Microchimica Acta published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wu, Haibo published the artcileEnantiorecognition ability of peptoids with α-chiral, aromatic side chains, Related Products of naphthyridine, the publication is Analyst (Cambridge, United Kingdom) (2011), 136(21), 4409-4411, database is CAplus and MEDLINE.

The enantiorecognition ability of oligomeric N-substituted glycines or “peptoids” with α-chiral, aromatic side chains was investigated by HPLC and ¹H NMR studies. For example, (S)-N-(1-phenylethyl)glycine (Nspe) was used as the monomer for the peptoids. The peptoids were synthesized with chloroacetyl chloride and (S)-α-phenylethylamine as submonomers in a homogeneous phase reaction. A series of peptoids with three to seven Nspe units were synthesized, followed by reaction with triethoxy (3-isocyanatopropyl)silane to generate the corresponding chiral monomers, and then, covalently bonded to the surface of spherical silica gel to obtain chiral stationary phases (CSPs 1-5). The chiral separation abilities of the CSPs for racemic BINOL and its derivatives were found to significantly depend on the chain length of the chiral selectors. The min. structural units required for resolving BINOL was found to be three. The enantioselectivities of of CSP-3 and CSP-4 were further evaluated by HPLC using 52 chiral analytes of wide structural variety. It was observed that possession of hydrogen bonding donors is a precondition for successful resolution on peptoid CSP.

Analyst (Cambridge, United Kingdom) published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C20H22ClN3O3, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Liu, Kun Ming published the artcileIron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using oxygen as an oxidant, COA of Formula: C22H18O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(6), 1124-1127, database is CAplus and MEDLINE.

An equivalent amount of N-heteroaryl and aryl Grignard or lithium reagents, after mediation by an equivalent of titanate, was facilely coupled to furnish N-heteroaryl-aryl compounds under the catalysis of FeCl₃/TMEDA at ambient temperature using oxygen as an oxidant. Most of the common N-heteroaryls were all good candidates, and thus provided a general, green and practical protocol for the flexible construction of various N-heteroaryl-aryl structures.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, COA of Formula: C22H18O2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Isojima, Yasushi published the artcileCkIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock, Formula: C20H17FO4S, the publication is Proceedings of the National Academy of Sciences of the United States of America (2009), 106(37), 15744-15749, S15744/1-S15744/74, database is CAplus and MEDLINE.

A striking feature of the circadian clock is its flexible yet robust response to various environmental conditions. To analyze the biochem. processes underlying this flexible-yet-robust characteristic, we examined the effects of 1260 pharmacol. active compounds in mouse and human clock cell lines. Compounds that markedly (>10 s.d.) lengthened the period in both cell lines, also lengthened it in-central clock tissues and peripheral clock cells. Most compounds inhibited casein kinase Iε (CKIε) or CKIδ phosphorylation of the PER2 protein. Manipulation of CKIε/δ-dependent phosphorylation by these compounds lengthened the period of the mammalian clock from circadian (24 h) to circabidian (48 h), revealing its high sensitivity to chem. perturbation. The degradation rate of PER2, which is regulated by CKIε/δ-dependent phosphorylation, was temperature-insensitive in living clock cells, yet sensitive to chem. perturbations. This temperature-insensitivity was preserved in the CKIε/δ-dependent phosphorylation of a synthetic peptide in vitro. Thus, CKIε/δ-dependent phosphorylation is likely a temperature-insensitive period-determining process in the mammalian circadian clock.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Morisaki, Yasuhiro published the artcileSynthesis and photoluminescence behaviors of anthracene-layered polymers, HPLC of Formula: 18512-55-5, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2014), 52(19), 2815-2821, database is CAplus.

Novel anthracene-layered polymers containing fluorescence quenchers such as ferrocene and nitrobenzene units at the polymer termini were designed and synthesized. Their optical properties were studied in detail. The photoluminescence spectra of the polymers were featureless without vibrational structures, indicating that the anthracenes are effectively interacting each other in a single polymer chain in the excited state. Fluorescence emission from the layered anthracene units was effectively quenched by the aromatic units at the polymer termini owing to energy and electron transfer through a single polymer chain. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, HPLC of Formula: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Lee, Yong-Kyung published the artcileFree-Radical Polymerization of (R)-(-)-1-(1-Naphthyl)ethyl(2-methacryloyloxyethyl)urea and Chiral Recognition Ability, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Macromolecules (2003), 36(13), 4735-4742, database is CAplus.

(R)-(-)-1-(1-Naphthyl)ethyl(2-methacryloyloxyethyl)urea (NEMOU) was synthesized from 2-methacryloyloxyethyl isocyanate (MOI) and (R)-(+)-1-(1-naphthyl)ethylamine. Radical homopolymerizations of NEMOU were performed in several solvents to obtain the corresponding chiral polymers that have hydrogen bonds based on urea moieties. Specific optical rotations of poly(NEMOU) changed by the measurement temperature, which may be attributed in part to change of conformation. From the results of radical copolymerizations of NEMOU with styrene (ST, M₂) or Me methacrylate (MMA, M₂), monomer reactivity ratios (r₁, r₂) and Alfrey-Price Q-e were determined: r₁ = 0.48, r₂ = 0.20, Q₁ = 1.41, e₁ = 0.74 for the NEMOU-ST system; r₁ = 0.55, r₂ = 0.16, Q₁ = 9.02, e₁ = 1.96 for the NEMOU-MMA system. The chiroptical property of the copolymers was strongly influenced by comonomer units. To examine the chiral recognition ability of poly(NEMOU), chiral stationary phases (CSPs) for high-performance liquid chromatog. (HPLC) were prepared from silica gel and poly(NEMOU). The CSPs resolved some racemates such as 1,2,3,4-tetrahydro-1-naphthol and N-benzyl-1-(1-methyl-2-methoxycarbonyl)ethylamine in n-hexane/2-propanol as mobile phase by HPLC. The chiral recognition ability of poly(NEMOU) may be ascribed not only to the interaction between the low mol. weight chiral selector and the racemates but also to the secondary and/or higher-ordered structure of the polymer.

Macromolecules published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Mashal, Mohammad Shafiq published the artcileSimultaneous quantification of 19 nonsteroidal anti-inflammatory drugs in oral fluid by liquid chromatography-high resolution mass spectrometry: Application on ultratrail runners oral fluid, HPLC of Formula: 59973-80-7, the publication is Drug Testing and Analysis (2022), 14(4), 701-712, database is CAplus and MEDLINE.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a therapeutic class suspected to be used by ultratrail runners. The use of NSAIDs during ultratrails is known to be associated with various adverse effects. To study the prevalence of NSAIDs intake in ultratrail runners, oral fluid (OF) is a relevant matrix as it is noninvasive and easy to collect. The aim of our work was to develop and validate a liquid-liquid extraction followed by a liquid chromatog. (LC)-mass spectrometry (MS)/high resolution mass spectrometry (HRMS) method for the simultaneous quantification of 19 NSAIDs in OF. After a comparison of different liquid-liquid extraction methods, a double step liquid-liquid extraction with chloroform was performed on OF collected with Quantisal, with extraction recoveries higher than 90%. An Accucore AQ column was selected for the chromatog. separation of NSAIDs. The Q Exactive Plus mass spectrometer operated in full scan and ddms2 mode after pos. and neg. electrospray ionization. Selectivity, carry-over, matrix effect, and linearity were validated for all NSAIDs. Within-day and between-day accuracy and precision were validated for all NSAIDs (<15% for quality control [QC] samples and <20% for lower limit of quantitation [LLOQ]), except within-day accuracy for the LLOQ of mefenamic acid. A stability study was also performed on OF at room temperature and +4°C. The method was applied on OF from runners who participate to Ultra Trail du Mont Blanc.

Drug Testing and Analysis published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, HPLC of Formula: 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Narayanan, Bhagavathi A. published the artcileRegression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model, Name: Sulindac sulfone, the publication is Clinical Cancer Research (2004), 10(22), 7727-7737, database is CAplus and MEDLINE.

Epidemiol. studies have revealed a decreased risk of colon cancer among people who have regularly taken cyclooxygenase (COX)-2 inhibitors such as aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Whereas the selective COX-2 inhibitor celecoxib and exisulind, a metabolic product of sulindac, have gained increasing attention as efficacious chemopreventive agents against colon and prostate cancer, not much is known about the underlying mol. targets and mechanisms. Moreover, the side effects of NSAIDs are a major obstacle for large-scale application to the prevention of cancer in humans; for example, in the United States in 1998, there were 16,550 deaths from NSAID-induced gastrointestinal complications. The toxicity associated with these compounds is raising concerns, and more needs to be known about their mode of action and mol. targets. We used the transgenic mouse prostate (TRAMP) model, which exhibits similarities with human prostate cancer, including epithelial origin, progression from the PIN stage to adenocarcinoma, and metastasis by a transgene that is hormonally regulated by androgens. In addition to histol. analyzing the PIN lesions of the dorsolateral prostate from TRAMP mice, we delineated the mol. targets and mechanisms of celecoxib and exisulind against mouse PIN lesions. We performed Western blot anal. of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-κB p65, BclII, AKT (total and phosphorylated Ser⁴⁷³), p53, cyclin-dependent kinase inhibitor p21^WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind. We found for the first time that (a) both celecoxib and exisulind as dietary supplements induce strong inhibitory effects against prostate cancer at doses of 800 and 500 ppm, resp., after 16 wk; (b) the histol. anal. of the dorsolateral prostate after 2 wk of treatment indicated a reduction of PIN lesions from 75% to 19% with celecoxib and to 16% with exisulind; (c) more importantly, those few PINs and adenocarcinomas in the groups treated with celecoxib or exisulind showed more apoptotic cells, lower levels of proliferating cell nuclear antigen, and a lower number of mitotic cells. To understand the mol. mechanisms involved in the inhibition of PIN lesions, first, we examined the expression of mol. targets involved in angiogenesis and inflammatory processes. It was clearly evident from Western blot anal. of the total protein lysate derived from the dorsolateral prostate tissues with PIN lesions that expression of androgen receptor, vascular endothelial growth factor, nuclear factor-κB p65, and BclII is down-regulated more effectively by celecoxib. Down-regulation of AKT protein (total and phosphorylated at Ser⁴⁷³) signaling by celecoxib clearly indicates an inhibition of the survival gene and the pathol. process that could otherwise lead to adenocarcinoma. Overall, the findings from this study clearly show the effectiveness of celecoxib and exisulind in reducing the PIN lesions by modulating a cascade of mol. targets involved in COX-2-dependent and -independent mechanisms. Whereas these agents are already in clin. trial or in use as chemopreventive agents, findings from this study demonstrate the difference in their mode of action, thus helping us to understand the side effects.

Clinical Cancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Name: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Scott, Lawrence T. published the artcileThermal migration of an ethynyl group from one benzene ring to another by reversible vinylidene C-H insertion, Recommanded Product: 9,10-Diethynylanthracene, the publication is Tetrahedron Letters (1997), 38(11), 1877-1880, database is CAplus.

Evidence is presented for the high temperature opening of a 5-membered ring by extrusion of a carbene (the reverse of a C-H bond insertion), which results in the net thermal migration of an ethynyl group from one benzene ring to another.

Tetrahedron Letters published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C14H15BF3NO2, Recommanded Product: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shweta published the artcileDesign-specific mechanistic regulation of the sensing phenomena of two Schiff bases towards Al³⁺, HPLC of Formula: 116-63-2, the publication is RSC Advances (2016), 6(60), 55430-55437, database is CAplus.

We report herein two optical probes (R1 and R2) for the fluorogenic detection of Al³⁺ at the level of 10^-8 M. R1 and R2 were synthesized by simple Schiff base condensation of 4-amino-3-hydroxy-1-naphthalene sulfonic acid with 5-bromosalicaldehyde and 2-hydroxy-1-naphthaldehyde, resp. The same were characterized by various spectroscopic techniques. R1 and R2 both underwent fluorescence emission upon their resp. interactions with Al³⁺ in an ethanol : water mixture (4 : 1, volume/volume). The binding modes of the receptors with Al³⁺ were studied through ¹H NMR spectroscopy, Job plots, and HR-MS, as well as through binding constant determination involving fluorescence titration data. The quenching of -C=N isomerization and of photoinduced electron transfer (PET) seem to be responsible for the fluorogenic switch-on situation of R1 and R2 with Al³⁺. At the same time, excited state intramol. proton transfer (ESIPT) also plays an important role in the ratiometric fluorescence response of R2, which is a consequence of a minor structural variation in R1 where the bromophenyl moiety is replaced with a naphthalene moiety. The mechanistic aspects of the sensing phenomenon are discussed in terms of ¹H NMR titration as well as theor. calculations at the d. functional level.

RSC Advances published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C17H14O5, HPLC of Formula: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem