Category: naphthyridine

Beitollahi, Hadi published the artcileApplication of a modified CuO nanoparticles carbon paste electrode for simultaneous determination of isoperenaline, acetaminophen and N-acetyl-L-cysteine, Computed Properties of 116-63-2, the publication is Electroanalysis (2016), 28(3), 645-653, database is CAplus.

A 1-[2-hydroxynaphthylazo]-6-nitro-2-naphthol-4-sulfonate/ CuO nanoparticles modified carbon paste electrode (HNNSCCPE) was constructed and the electro-oxidation of isoprenaline at the surface of the modified electrode was studied using cyclic voltammetry (CV), chronoamperometry (CHA), and square wave voltammetry (SWV). Under the optimized conditions, the square wave voltammetric peak current of isoprenaline increased linearly with isoprenaline concentrations in the range of 1.0×10^-7 to 7.0×10^-4 M and detection limit of 5.0×10^-8 M was obtained for isoprenaline. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of isoprenaline, acetaminophen and N-acetyl-L-cysteine which makes it suitable for the detection of isoprenaline in the presence of acetaminophen and N-acetyl-L-cysteine in real samples.

Electroanalysis published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Qian, Yan published the artcileSpiro[fluorene-9,9�xanthene]-based universal hosts for understanding structure-property relationships in RGB and white PhOLEDs, SDS of cas: 159-62-6, the publication is RSC Advances, database is CAplus.

Ingenious construction of state-of-the-art models of electrophosphorescent hosts for uncovering the deep role of different mol. modifications in PhOLEDs performances is crucial for rational cumulative improvements of device efficiency and for accelerating their commercialization. A series of conjugation-interrupted spiro[fluorene-9,9â€?xanthene](SFX)/9-arylfluorenes (AFs) hybrid host materials have been designed and synthesized by concise two-step reactions, and have been demonstrated to serve as universal hosts for low voltage blue, green, red and single-emitting layer white PhOLEDs. By varying the electronegativity and position of the bulky AF substitutes, two independent, selective methods for fine tuning frontier MO energy levels without affecting the high triplet energy level (T₁) have been realized. This offers either facilitated hole- or electron-injection/blocking without influencing the optical properties, which can explain the performance of the corresponding RGB PhOLEDs. This investigation provides good guidance for the future rational design of high-performance PhOLED hosts by accumulative structural modifications.

RSC Advances published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C25H16O, SDS of cas: 159-62-6.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhong, Min published the artcileCarcinogenicity Prediction of Noncongeneric Chemicals by a Support Vector Machine, Application In Synthesis of 59973-80-7, the publication is Chemical Research in Toxicology (2013), 26(5), 741-749, database is CAplus and MEDLINE.

The ability to identify carcinogenic compounds is of fundamental importance to the safe application of chems. In this study, the authors generated an array of in silico models allowing the classification of compounds into carcinogenic and noncarcinogenic agents based on a data set of 852 noncongeneric chems. collected from the Carcinogenic Potency Database (CPDBAS). Twenty-four mol. descriptors were selected by Pearson correlation, F-score, and stepwise regression anal. These descriptors cover a range of physicochem. properties, including electrophilicity, geometry, mol. weight, size, and solubility The descriptor mutagenic showed the highest correlation coefficient with carcinogenicity. On the basis of these descriptors, a support vector machine-based (SVM) classification model was developed and fine-tuned by a 10-fold cross-validation approach. Both the SVM model (Model A1) and the best model from the 10-fold cross-validation (Model B3) runs gave good results on the test set with prediction accuracy over 80%, sensitivity over 76%, and specificity over 82%. In addition, extended connectivity fingerprints (ECFPs) and the Toxtree software were used to analyze the functional groups and substructures linked to carcinogenicity. It was found that the results of both methods are in good agreement.

Chemical Research in Toxicology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C10H16Br3N, Application In Synthesis of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

El-Sayed, Amira A. published the artcileDesign, synthesis, anticancer evaluation and molecular docking study of novel 2,4-dichlorophenoxymethyl-based derivatives linked to nitrogenous heterocyclic ring systems as potential CDK-2 inhibitors, COA of Formula: C10H9NO4S, the publication is Journal of Molecular Structure (2022), 131285, database is CAplus.

A novel series of 2,4-dichlorophenoxymethyl-based derivatives 4-18 bearing various nitrogenous heterocyclic systems have been designed and synthesized through mol. hybridization approach. The anti-proliferative activity of all newly synthesized derivatives was established against human HCT-116 and MCF-7 cancer cell lines. The structure-activity relationship (SAR) studies exhibited that the derivatives incorporated with pyrido[3,2-d]pyrimidine, naphtho[2,3-e][1,3]oxazine-5-sulfonic acid, benzo[d]thiazole and benzo[d]oxazole scaffolds revealed the highest cytotoxic activities comparing with doxorubicin as a reference drug. The promising derivatives 5, 9, 13 and 15 were subjected to enzymic inhibitory assessment against CDK-2/cyclin A2 using roscovitine as a standard Concerning their effects upon the apoptotic process, they upregulated Bax, p-53 and caspase-3 levels and downregulated Bcl-2, causing induction of apoptosis. Moreover, the in silico mol. docking was applied to investigate the possible binding modes and orientations within the active site of CDK-2.

Journal of Molecular Structure published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, COA of Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sancho, Raquel published the artcileMonolithic silica columns functionalized with substituted polyproline-derived chiral selectors as chiral stationary phases for high-performance liquid chromatography, Quality Control of 2960-93-2, the publication is Journal of Separation Science (2014), 37(20), 2805-2813, database is CAplus and MEDLINE.

In this study, two polyproline-derived chiral selectors are bonded to monolithic silica gel columns. In spite of high chiral selector coverage, the derivatization was found to have only a slight effect on the hydrodynamics of the mobile phase through the column. The enantioseparation ability of the resulting chiral monolithic columns was evaluated with a series of structurally diverse racemic test compounds When compared to analogous bead-based chiral stationary phases, higher enantioseparation and broader application domain were observed for monolithic columns. Moreover, the increase in flow rate produces a minor reduction of resolution, which permits to shorten anal. time. Addnl., increased loadability defines chiral polyproline derived monoliths as adequate for preparative chromatog.

Journal of Separation Science published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Quality Control of 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hirose, Daisuke published the artcileEnantioseparation on helical poly(diphenylacetylene)s bearing optically-active pendants: Effects of differences in higher-order structures of kinetically-trapped and thermodynamically-stable states on chiral recognition ability, Product Details of C22H18O2, the publication is Journal of Chromatography A (2022), 463164, database is CAplus and MEDLINE.

An optically-active poly(diphenylacetylene) (PDPA) bearing carboxy pendant groups with left-handed helicity memory (M-h-poly-1), synthesized using the noncovalent helicity-induction-and-memory strategy, was converted into a PDPA bearing optically-active pendant groups through an amide bonding (M-h_KT-poly-2S), while maintaining the left-handed helicity memory, by reaction with (S)-1-phenylethylamine ((S)-2) using a condensing reagent at room temperature Its chiral recognition ability was investigated as a chiral stationary phase (CSP) for high-performance liquid chromatog. (HPLC). M-h_KT-poly-2S exhibited significantly different chiral recognition ability towards racemates compared to the previously reported corresponding helical PDPA bearing the same optically-active pendant groups (M-h_TS-poly-2S) (prepared by the reaction of an optically-inactive PDPA bearing carboxy pendants with (S)-2, followed by thermal annealing, to induce a left-handed helical structure in the polymer main chain). Although the main chains of both M-h_KT-poly-2S and M-h_TS-poly-2S formed almost completely left-handed helical structures, their higher-order structures varied slightly, as confirmed by various spectroscopic methods (UV-Vis, CD (CD), IR, and vibrational CD). M-h_KT-TS-poly-2S, the PDPA formed on the thermal annealing of M-h_KT-poly-2S, exhibited the same higher-order structure and chiral discrimination ability as M-h_TS-poly-2S. Therefore, slight differences in the higher-order structures of the kinetically-trapped metastable state (M-h_KT-poly-2S) and the thermodynamically-stable state (M-h_TS-poly-2S), due to differences in synthetic procedures, significantly impact their chiral recognition abilities as CSPs, even with identical primary structures and helix-sense of the polymer main chain.

Journal of Chromatography A published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Product Details of C22H18O2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Maeyama, Katsuya published the artcileNickel complex-mediated synthesis of optically active wholly aromatic polyketones bearing 2,2′-dimethoxy-1,1′-binaphthyl-6,6′-ene units, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Polymer Journal (Tokyo, Japan) (2005), 37(10), 736-741, database is CAplus.

Two 6,6′-Bis(chlorobenzoyl)-2,2′-dimethoxy-1,1′-binaphthyls (3,3′-Cl and 4,4′-Cl) are prepared via P₂O₅-MsOH mediated regioselective diaroylation of 2,2′-dimethoxy-1,1′-binaphthyl. NiBr₂/Zn-mediated aromatic coupling polymerization of 6,6′-bis(chlorobenzoyl)-2,2′-dimethoxy-1,1′-binaphthyls yields the corresponding wholly aromatic polyketones. When optically active bis(chlorobenzoylated) binaphthyls are employed, optically active wholly aromatic polyketones with large sp. rotations, excellent thermal resistance, and excellent solubility to organic solvents are obtained.

Polymer Journal (Tokyo, Japan) published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Safety of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Maeyama, Katsuya published the artcileP₂O₅-MsOH-mediated regioselective diaroylation of 2,2′-dimethoxy-1,1′-binaphthyl, Formula: C22H18O2, the publication is Synthetic Communications (2004), 34(17), 3243-3250, database is CAplus.

Phosphorus pentoxide-methanesulfonic acid (P₂O₅-MsOH) mediated electrophilic aromatic substitution diaroylation of 2,2′-dimethoxy-1,1′-binaphthyl with several aromatic carboxylic acids proceeds to afford 6,6′-diaroylated adducts as single regioisomers.

Synthetic Communications published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Formula: C22H18O2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Morisue, Mitsuhiko published the artcileFully Conjugated Porphyrin Glass: Collective Light-Harvesting Antenna for Near-Infrared Fluorescence beyond 1 μm, Product Details of C18H10, the publication is ACS Omega (2018), 3(4), 4466-4474, database is CAplus and MEDLINE.

Expanded π-systems with a narrow HOMO-LUMO band gap encounter deactivation of excitons due to the “energy gap law” and undesired aggregation. This dilemma generally thwarts the near-IR (NIR) luminescence of organic π-systems. A sophisticated cofacially stacked π-system is known to involve exponentially tailed disorder, which displays exceptionally red-shifted fluorescence even as only a marginal emission component. Enhancement of the tail-state fluorescence might be advantageous to achieve NIR photoluminescence with an expected collective light-harvesting antenna effect as follows: (i) efficient light-harvesting capacity due to intense electronic absorption, (ii) a long-distance exciton migration into the tail state based on a high spatial d. of the chromophore site, and (iii) substantial transmission of NIR emission to circumvent the inner filter effect. Suppression of aggregation-induced quenching of fluorescence could realize collective light-harvesting antenna for NIR-luminescence materials. This study discloses an enhanced tail-state NIR fluorescence of a self-standing porphyrin film at 1138 nm with a moderate quantum efficiency based on a fully π-conjugated porphyrin that adopts an amorphous form, called “porphyrin glass”.

ACS Omega published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Product Details of C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Alvey, Paul M. published the artcileConjugated NDI-Donor Polymers: Exploration of Donor Size and Electrostatic Complementarity, Name: 9,10-Diethynylanthracene, the publication is Macromolecules (Washington, DC, United States) (2013), 46(3), 718-726, database is CAplus.

Conjugated donor-acceptor copolymers comprised of electron-deficient 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) linked to a series of relatively electron-rich aromatics via ethynyl spacers were synthesized and characterized. While LUMO levels remained constant at -3.75 eV, HOMO levels were sensitive to the relatively electron-rich aromatic donors and systematically tuned from -5.68 to -5.17 eV. Regardless of the electron-rich comonomer, fluorescence and x-ray diffraction data were consistent with the polymer chains being assembled through the stacking of NDI moieties in an offset face-to-face fashion rather than alternating donor-acceptor stacks.

Macromolecules (Washington, DC, United States) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Name: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem