Category: naphthyridine

Andrews, Michael published the artcileA luminescent rhenium(I) complex of 2,7-dimethyl-1,8-naphthyridine: Synthesis, spectroscopy and X-ray crystal structure, Category: naphthyridine, the publication is Transition Metal Chemistry (Dordrecht, Netherlands) (2009), 34(5), 493-497, database is CAplus.

2,7-Dimethyl-1,8-naphthyridine (L¹) reacts with pentacarbonylchlororhenium in toluene or chloroform to give the target complex fac-{ReCl(CO)₃(L¹)}. X-ray crystallog. data were obtained for fac-{ReCl(CO)₃(L¹)}. The structural and ¹H NMR data suggest that the ligand coordinates to the rhenium in a bidentate fashion in both solid and solution states. The complex also is luminescent in both solution and solid states. The fluxionality of the ligand in solution causes ligand-centered emission to be observed in solution, whereas only ³MLCT emission was observed in the solid state. Although the complex was air-stable, the lability of L¹ was studied in ¹H NMR experiments where CD₃OD induced complete ligand dissociation over 24 h, and also in reaction of fac-{ReCl(CO)₃(L¹)} with one equivalent of 2,2′-bipyridine in chloroform which resulted in quant. ligand exchange.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wong, Wai-Yeung published the artcileSynthesis and characterization of new oligoacetylenic silanes, Formula: C18H10, the publication is New Journal of Chemistry (2002), 26(3), 354-360, database is CAplus.

Synthetic routes to a series of novel oligoacetylenic silanes with or without (hetero)aromatic bridges have been developed. The compound Me₃SiC顚咰Si(Ph)₂C顚咰SiMe₃ was first prepared, which was selectively desilylated with CaCO₃ in methanol at room temperature to afford the mono-protected bis(alkynyl)silane Me₃SiC顚咰Si(Ph)₂C顚咰H in moderate yield. Treatment of this mono-protected species with ⁿBuLi, followed by silylation with Ph₂SiCl₂, gives a good yield of Me₃SiC顚咰Si(Ph)₂C顚咰Si(Ph)₂C顚咰Si(Ph)₂C顚咰SiMe₃, with alternating silicon and acetylene units. A range of linear silicon-linked oligoalkynes containing phenylene, bithienylene and anthrylene rings, HC顚咰RC顚咰Si(Ph)₂C顚咰RC顚咰H and HC顚咰RC顚咰Si(Ph)₂C顚咰RC顚咰Si(Ph)₂C顚咰RC顚咰H (R = 1,4-phenylene, 5,5′-bithienylene or 9,10-anthrylene), were synthesized by condensation reactions of Ph₂SiCl₂ with the components obtained in situ from a HC顚咰RC顚咰H-ⁿBuLi mixture in THF and the products were isolated by chromatog. on silica. All these new compounds have been characterized by IR, ¹H and ¹³C NMR and UV/VIS spectroscopies and mass spectrometry. The single-crystal x-ray structure of HC顚咰(p-C₆H₄)C顚咰Si(Ph)₂C顚咰(p-C₆H₄)C顚咰Si(Ph)₂C顚咰(p-C₆H₄)C顚咰H has been determined, showing that two silicon atoms and six acetylene units constitute the backbone of the mol.

New Journal of Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C19H14FN3O3S, Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kwak, Min Seob published the artcileNovel candidate drugs in anti-tumor necrosis factor refractory Crohn’s diseases: in silico study for drug repositioning, Recommanded Product: Sulindac sulfone, the publication is Scientific Reports (2020), 10(1), 10708, database is CAplus and MEDLINE.

Abstract: Biologicals like anti-tumor necrosis factor (TNF) therapy for Crohn’s disease (CD) are safe and effective but there is a significant rate of primary and secondary nonresponse in the patients. In this study, we applied a computational approach to discover novel drug therapies for anti-TNF refractory CD in silico. We use a transcriptome dataset (GSE100833) for the anti-TNF refractory CD patients from NCBI GEO. After co-expression anal., we specifically investigated the extent of protein-protein interactions among genes in clusters based on a protein-protein interaction database, STRING. Pathway anal. was performed using the clEnrich function based on KEGG gene sets. Co-expressed genes in cluster 1, 2, 3, 4, up or down-regulated genes and all differentially expressed genes are highly connected. Among them, cluster 1, which is highly enriched for chemokine signaling, also showed enrichment for cytokine-cytokine receptor interaction and identifies several drugs including cyclosporin with known efficacy in CD. Vorinostat, histone deacetylase inhibitors, and piperlongumine, which is known to have inhibitory effect on activity of NF-kB, were also identified. Some alkaloids were also selected as potential therapeutic drugs. These finding suggest that they might serve as a novel therapeutic option for anti-TNF refractory CD and support the use of public mol. data and computational approaches to discover novel therapeutic options for CD.

Scientific Reports published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Lim, Soo-Jeong published the artcileP38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis, Application In Synthesis of 59973-80-7, the publication is Oncology Reports (2006), 16(5), 1131-1135, database is CAplus and MEDLINE.

Sulindac sulfone (exisulind), is a promising anti-cancer agent because of its ability to induce apoptosis in a variety of malignant cell types and its minimal toxicity to normal cells. The induction of apoptosis is thought to account for the growth inhibitory effect of exisulind. The mitogen-activated protein kinase (MAPK) cascade has been implicated in the regulation of apoptosis in response to exisulind. With human SNU-C4 colon cancer cells that were much more resistant to exisulind than other colon cancer cells, in this study, we investigated whether the modulation of MAPK activity by using selective MAPK inhibitors can contribute to sensitizing SNU-C4 cells to exisulind. Exisulind (400 and 600 渭M) slightly increased the phosphorylation of pERK1/2 but pretreatment with the pERK1/2 inhibitor PD98059 did not significantly change the apoptotic response of SNU-C4 cells. The same doses of exisulind increased the phosphorylation of p38MAPK, and pretreatment with the p38MAPK inhibitor SB203580 significantly potentiated growth inhibition and apoptosis induced by exisulind in SNU-C4 cells. We further found that apoptosis induced by a combination of exisulind and SB203580 was mediated through caspase activation. Collectively, our findings indicate that selective p38MAPK inhibitors potentiate apoptosis induction by exisulind in SNU-C4 cells. Such combinations may provide a more effective and less toxic strategy for the prevention or treatment of colon cancer.

Oncology Reports published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Application In Synthesis of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Lim, Soo-Jeong published the artcileAlpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis, Name: Sulindac sulfone, the publication is Apoptosis (2007), 12(2), 423-431, database is CAplus and MEDLINE.

Sulindac sulfone (also known as exisulind) and its chem. derivatives are promising anticancer agents capable of inducing apoptosis in a variety of malignant cell types with minimal toxicity to normal cells. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising anticancer agent, to sensitize colon cancer cells to exisulind-induced apoptosis. We found that sub-apoptotic doses of TOS greatly enhanced exisulind-induced growth suppression and apoptosis in the HCT116, LoVo and SNU-C4 human colon cancer cell lines. Our results revealed that this was accounted for primarily by an augmented cleavage of poly(ADP-ribose) polymerase (PARP) and enhanced activation of caspase-8, -9 and -3. Pretreatment with z-VAD-FMK (a pan-caspase inhibitor), z-IETD-FMK (a caspase-8 inhibitor) or z-LEHD-FMK (a caspase-9 inhibitor) blocked TOS and exisulind cotreatment-induced PARP cleavage and apoptosis. Furthermore, TOS/exisulind cotreatment induced JNK phosphorylation, while pretreatment with SP600151 (a JNK inhibitor) partially blocked cotreatment-induced caspase-dependent PARP cleavage and apoptosis. Taken together, these findings indicate that TOS sensitizes human colon cancer cells to exisulind-induced apoptosis. Apoptotic synergy induced by exisulind plus TOS seems likely to be mediated through a mechanism involving activation of caspases and JNK.

Apoptosis published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Name: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Webster, W. Scott published the artcileExisulind in the treatment of prostate cancer, Recommanded Product: Sulindac sulfone, the publication is Expert Review of Anticancer Therapy (2005), 5(6), 957-962, database is CAplus and MEDLINE.

A review. Prostate cancer represents the most common noncutaneous malignancy in men. With the widespread use of prostate-specific antigen screening, as many as one in six men in the USA will be diagnosed with prostate cancer. Significant healthcare resources are currently devoted to the treatment of this disease, specifically aimed at improving the side effects of successful treatment. Surgery or radiation therapy provides the best chance of cure from this disease. However, as many as 50% of patients treated with curative intent will develop a recurrence 10-15 years following treatment. Hormonal ablation via medical or surgical castration provides disease control, but is associated with significant hot flushes, loss of libido and impotence. Selective, apoptotic antineoplastic drugs, such as exisulind, may provide an alternative method to treating or preventing prostate cancer. This drug profile reviews the evidence for the use of exisulind in the treatment of prostate cancer.

Expert Review of Anticancer Therapy published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C5H5NO3S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Romeiro, Nelilma C. published the artcileSynthesis, pharmacological evaluation and docking studies of new sulindac analogues, Product Details of C20H17FO4S, the publication is European Journal of Medicinal Chemistry (2009), 44(5), 1959-1971, database is CAplus and MEDLINE.

This paper describes the synthesis, pharmacol. evaluation and docking studies of a series of new sulindac analogs. Overall, the designed compounds revealed good, in vivo, antinociceptive activity and satisfactory anti-inflammatory profile. Flexible mol. docking with COX-1/COX-2 has shown putative binding modes of the designed compounds while the theor. evaluation of cell permeability based on Lipinski’s rule of five has helped rationalize the biol. results.

European Journal of Medicinal Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Product Details of C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Berton, Nicolas published the artcileCopolymer-Controlled Diameter-Selective Dispersion of Semiconducting Single-Walled Carbon Nanotubes, Product Details of C12H6F6O6S2, the publication is Chemistry of Materials (2011), 23(8), 2237-2249, database is CAplus.

The ability of a series of strictly alternating copolymers to selectively enwrap single-walled carbon nanotubes (SWNTs) is studied. Seven copolymers comprising either fluorene or carbazole subunits separated by naphthalene, anthracene, and anthraquinone spacers are obtained in good yields via a Suzuki cross-coupling protocol. The 1,5-linked naphthalene, anthracene, and anthraquinone units are introduced to favor a spiral conformation of the polymer backbone to improve its SWNT wrapping features. Particularly high yields of polymers are obtained using the naphthalene-1,5-ditriflate precursor, highlighting the potential of bifunctional aryltriflates as precursors of copolymers. All polymers disperse HiPco SWNTs in toluene. The obtained dispersions are purified by d. gradient centrifugation and their compositions are analyzed by photoluminescence (PL) spectroscopy. In their dispersing ability the polymers display more or less pronounced SWNT diameter selectivity. In particular, poly(9,9-didodecylfluorene-2,7-diyl-alt-anthracene-1,5-diyl) (P2) exhibits a strong selectivity toward SWNTs having a diameter of 鈮?.95 nm, including close-to-zigzag nanotubes. SWNT dispersions of P2 are further analyzed by absorbance and Raman scattering spectroscopy. The diameter selectivity is attributed to the anthracene-1,5-diyl subunit. In order to combine diameter selectivity with the preference for large chiral angles as shown by polyfluorene, the number of fluorene subunits in the polymer backbone is doubled in P7. Indeed, to some extent, the combination of both selectivities is observed in its dispersing behavior.

Chemistry of Materials published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Product Details of C12H6F6O6S2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gu, Yang published the artcileCooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides, COA of Formula: C11H8F2, the publication is Nature Communications (2014), 5405, database is CAplus and MEDLINE.

A cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions is reported. The system is developed by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide, and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine.

Nature Communications published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, COA of Formula: C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ermolaev, Nikolai L. published the artcileTris(trifluoromethyl)germylethynyl derivatives of biphenyl and anthracene: Synthesis, structure, and evidence of the intramolecular charge transfer on the germanium center, Category: naphthyridine, the publication is Journal of Organometallic Chemistry (2015), 83-95, database is CAplus.

Sym. and unsym. 4,4′-disubstituted 1,1′-biphenyl, and 9,10-anthracene derivatives with tris(trifluoromethyl)germylethynyl -C顚咰Ge(CF₃)₃ substituents have been prepared, their properties have been studied and compared with those of dimethyl(phenyl)silylethynyl -C顚咰Si(Ph)Me₂ compounds UV-visible absorption, steady-state, and time-resolved fluorescence spectra in solution for this germanium and silicon compounds have been investigated. The process of photoinduced electron-transfer from the aromatic group to the germanium center has been found in the unsym. 4-biphenyl -C顚咰Ge(CF₃)₃ mol. Anthracene derivatives with -C顚咰Ge(CF₃)₃ substituents have been characterized crystallog.

Journal of Organometallic Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem