Category: naphthyridine

Fabre, Muriel A. published the artcileSynthesis of novel mononuclear and dinuclear ruthenium(II) complexes with terpyridine and acetylacetonate ancillary ligands and cyanamide derivative ligands, Application In Synthesis of 18512-55-5, the publication is Inorganica Chimica Acta (2005), 358(7), 2384-2394, database is CAplus.

Several new mononuclear and dinuclear Ru(II) complexes incorporating 2,2′:6′,2”-terpyridine and acetylacetonate as ancillary ligands and phenylcyanamide derivative ligands [Ru(tpy)(acac)(L)] and [{Ru(tpy)(acac)}₂(μ-L’)] (tpy = 2,2′:6′,2”-terpyridine, acac = acetylacetonate, L = hmbpcyd = 4-(3-hydroxy-3-methylbutynyl)phenylcyanamide anion (2) and epcyd = 4-ethynylphenylcyanamide anion (3) and L’ = bcpda = bis(4-cyanamidophenyl)diacetylene dianion (4) and bcpea = 9,10-bis(4-cyanamidophenylethynyl)anthracene dianion (5)) were synthesized in a stepwise manner starting from [Ru(tpy)(acac)(Ipcyd)] (1), where Ipcyd = 4-iodophenylcyanamide anion. Ph₄As⁺ salts of the phenylcyanamide derivative ligands were also prepared The four complexes were characterized by UV-visible, IR, ES-MS, electrochem. and ¹H NMR. Mononuclear complexes 2 and 3 were further characterized by ¹³C NMR. The single crystal x-ray structure of 2 was determined, it crystallized with one mol. of H₂O with empirical formula of C₃₂H₃₁N₅O₅Ru, in a monoclinic crystal system and space group of P2₁/n with a 17.642(5), b 9.634(2), c 20.063(7) Å, β 92.65(3)° and Z = 4. The structure was refined to a final R factor of 0.040. The Ru(III/II) couple of 1–3 appeared around 0.34 V vs. the SCE in DMF and at a slightly higher potential, around 0.36-0.37 V for 4 and 5. Spectroelectrochem. studies were also performed for 4 and 5, no intervalence transition was observed despite all attempts.

Inorganica Chimica Acta published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Application In Synthesis of 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wu, Haibo published the artcileInvestigation of brush-type chiral stationary phases based on O,O’-diaroyl tartardiamide and O,O’-bis-(arylcarbamoyl) tartardiamide, Application of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Journal of Separation Science (2012), 35(3), 351-358, database is CAplus and MEDLINE.

Four chiral organosilanes based on O,O’-dibenzoyl tartardiamide, O,O’-bis-(3,5-dimethylbenzoyl) tartardiamide, O,O’-bis-(phenylcarbamoyl) tartardiamide and O,O’-bis-[(3,5-dimethylphenyl)carbamoyl] tartardiamide were synthesized and immobilized on silica to afford corresponding brush-type chiral stationary phases (CSPs) with well-defined structures. Using 54 compounds containing a wide variety of structures as analytes, the enantioselectivities of the four CSPs were evaluated under normal-phase modes. 3,5-Di-Me substituent in the aryl group was found to significantly affect the enantioselectivity of CSPs containing aryl ester moieties. Aryl carbamate moieties in CSPs were observed more beneficial for enantioseparation than aryl ester moieties. The addnl. hydrogen-bond donors (NH) present in the carbamate groups contributed greatly to the enantioselectivity of CSPs, which is contrary to the results that were found in network-polymeric CSPs.

Journal of Separation Science published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C7H7BF2O3, Application of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fu, Wen-Fu published the artcileSynthesis, characterization, photoinduced isomerization, and spectroscopic properties of vinyl-1,8-naphthyridine derivatives and their copper(I) complexes, Related Products of naphthyridine, the publication is Inorganic Chemistry (2010), 49(10), 4524-4533, database is CAplus and MEDLINE.

Acetylamino-substituted 2-pyridinylvinyl-1,8-naphthyridine ligands and their copper(I) phosphine mono- and binuclear complexes were prepared and characterized by x-ray crystal structure determination A series of 2-(2-pyridinylvinyl) 1,8-naphthyridine ligands, 7-acetamido-2-(6-acetamido-2-pyridinylethenyl)-4-methyl-1,8-naphthyridine (L¹), 2-(6-acetamido-2-pyridylethenyl)-1,8-naphthyridine (L²), 7-(6-acetamido-2-pyridinylethenyl)-5-methyl-1,8-naphthyridin-2(1H)-one (L³), 2-(2-diacetylamino-3-pyridinylethenyl)-7-(diacetylmethylene)-7,8-dihydro-1,8-naphthyridine (L⁴), and 2-(2-diacetylamino-3-pyridinylethenyl)-7-acetylpyrrolo[1,2-a]-1,8-naphthyridine (L⁵), as well as copper(I) phosphine complexes I, [CuL¹(PCy₃)](BF₄) (1, I·BF₄, M, Y¹ void, Y = tricyclohexylphosphine), [Cu₂L¹(PPh₃)₄](BF₄)₂ [2, I·2BF₄, M = Cu, Y = Y¹ = (PPh₃)₂,], [Cu₂L¹(dppm)](BF₄)₂ (3, I·2BF₄, M = Cu, Y-Y¹ = dppm), and [Cu₂(L¹)(dcpm)](BF₄)₂ [4, I·2BF₄, M = Cu, Y-Y¹ = bis(dicyclohexylphosphino)methane] were prepared All these compounds, except for L¹ and L², were characterized by single crystal x-ray diffraction anal., and a comprehensive study of their spectroscopic properties involving TD-DFT theor. calculations is presented. An intramol. 1,3-hydrogen transfer takes place during the formation of L³ and L⁴, which in the case of the latter plays an important role in the 1,5-dipolar cyclization into L⁵. The spectral changes that originate from an intramol. charge transfer (ICT) in the form of a π_py→π*_napy transition can be tuned through acid/base-controlled switching for L¹-L³. Ligands L¹-L³, complexes 1 and 2 undergo photochem. (E)-(Z)-double bond isomerization under 365 nm light irradiation due to their flexible structures. Quantum chem. calculations revealed that the dinuclear complexes with structural asymmetry exhibit different metal-to-ligand charge-transfer transitions.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ou, Ya-Ping published the artcileSynthesis, Characterization, and Properties of Anthracene-Bridged Bimetallic Ruthenium Vinyl Complexes [RuCl(CO)(PMe₃)₃]₂(μ-CH:CH-anthracene-CH:CH), Name: 9,10-Diethynylanthracene, the publication is Organometallics (2011), 30(21), 5763-5770, database is CAplus.

Four anthracene-based bimetallic Ru vinyl complexes, in which two Ru units are attached at different positions (the 9,10-, 1,5-, 2,6-, and 1,8-positions) of the anthracene moiety, were synthesized by treating the appropriate anthracene-based ethynes with [RuHCl(CO)(PPh₃)₃]. These bimetallic complexes were thoroughly characterized by NMR, x-ray diffraction, and elemental anal. According to the single-crystal x-ray structures, the 2,6-disubstituted Ru vinyl complex has a more planar structure compared with the 9,10-disubstituted complex, possibly because it has less steric hindrance. Also, the optical electronic properties of these complexes were studied, such as their UV/visible absorption spectra, fluorescence spectra, and electrochem. properties. The optical electronic results indicated that the 2,6-disubstituted Ru vinyl complex displayed the strongest fluorescence emission due to the more planar structure of its organic conjugated bridge, and the electrochem. studies showed that the two Ru centers displayed obvious differences in electronic communication when they are located at different positions on the anthracene unit, with the 9,10- and 1,8-disubstituted Ru vinyl complexes exhibiting better electronic communication and higher stability of the mixed-valence complex than the 1,5- and 2,6-disubstituted complexes.

Organometallics published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Name: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Cao, Gui-Ping published the artcileRapid and environmentally friendly determination of trace nitrite in water under combined effects of cetyltrimethyl ammonium bromide and β-cyclodextrin, Category: naphthyridine, the publication is Desalination and Water Treatment (2019), 259-267, database is CAplus.

Nitrite is a characteristic pollutant in natural water. A simple, rapid and highly selective spectrofluorimetric method for determination of trace nitrite has been developed. It was based on the fact that nitrite reacted rapidly with iodide at room temperature and led to the fluorescence quenching of 4′,5′-dibromofluorescein (DBF) under the combined effects of cetyltrimethyl ammonium bromide (CTAB) and β-cyclodextrin (β-CD). The fluorescence intensity of the above reaction system was measured with excitation and emission wavelengths of 532 and 551 nm, resp. Optimal values of the main factors involving volumes of CTAB, β-CD and sulfuric acid were explored by a Box-Behnken design. Under the optimized exptl. conditions, the fluorescence quenching intensity was good linear over a nitrite concentration range of 0.2-46.0μg/L with a correlation coefficient better than 0.998. The detection limit of 0.16μg/L was obtained for the determination of nitrite by the proposed method. The general coexisting ions did not interfere to the reactions of nitrite with iodide and DBF. The relative standard deviation of the method for the determination of nitrite in water samples was below 2.7%, and the corresponding recoveries were between 92.1% and 107.9%. The proposed method is environmentally friendly and suitable for water monitoring.

Desalination and Water Treatment published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kobayashi, Eiichi published the artcileNovel conjugated polymer containing anthracene backbone: addition polymers of 1,4-benzenedithiol with 9,10-diethynylanthracene and its conductivity, Formula: C18H10, the publication is Polymer Journal (Tokyo, Japan) (1990), 22(3), 266-73, database is CAplus.

The addition polymerization of 1,4-benzenedithiol to 9,10-diethynylanthracene, which was freshly prepared before use, was carried out in a THF and benzene solution at 50-60° under N atm. by various initiation methods such as UV irradiation, AIBN, and Bz₂O₂. The yield of polymer was affected seriously by the initiation mode. Both the yield and the mol. weight are higher for the polymer prepared by UV irradiation than that prepared by means of AIBN or Bz₂O₂. By UV irradiation, the yield of the polymer was âˆ?0%, and the number-average mol. weight of the polymer obtained in THF was âˆ?0,000, which was one order higher than that of the polymer obtained in benzene. The elec. conductivity of the polymer was on the order of 10^-13 Scm^-1 without doping, but increased up to 10^-6 Scm^-1 on I₂ doping. The diffuse reflectance spectra of the polymer indicated a relatively lower band gap (âˆ?.77 eV), and at 1.46 eV and 0.86 eV small peaks appeared, which could be attributed to a polaron or bipolaron in the polymer backbone.

Polymer Journal (Tokyo, Japan) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kobayashi, Eiichi published the artcileNovel conjugated polymer containing anthracene backbone: competitive addition polymerization of dithiol monomers to diethynyl monomers and relative reactivity, SDS of cas: 18512-55-5, the publication is Polymer Journal (Tokyo, Japan) (1990), 22(2), 146-52, database is CAplus.

Competitive addition polymerizations of 9,10-anthracenedithiol (I), 4,4′-biphenyl-dithiol(II), and 1,4-benzenedithiol (III) to 9,10-diethynylanthracene (IV), 4,4′-diethynylbiphenyl (V), and 1,4-diethynylbenzene (VI) were carried out in THF at 50° by UV irradiation under a nitrogen atm., and the relative reactivities of the monomers were discussed on the basis of composition anal. for the obtained polymers. To the dithiol monomers, the relative reactivities of the diethynyl monomers were in the order of IV > V > VI. The relative reactivities of dithiol monomers to the diethynyl monomers were in the order of I > II > III. This indicated that the more the monomer conjugation, the higher was the relative reactivity. The high reactivities of anthracene derivatives would be caused from stabilization of the intermediate carbon radical and thio radical by its high conjugation system.

Polymer Journal (Tokyo, Japan) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, SDS of cas: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kobayashi, Eiichi published the artcileNovel conjugated polymer containing anthracene backbone: addition polymer of 9,10-diethynylanthracene with 9,10-anthracenedithiol and its properties, HPLC of Formula: 18512-55-5, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1990), 28(10), 2641-50, database is CAplus.

9,10-Diethynylanthracene (I) was prepared by alk. hydrolysis of 9,10-bis(trimethylsilylethynyl)anthracene. Another monomer, 9,10-anthracenedithiol (II), was prepared by reduction of anthracene polydisulfide. A crystalline conjugated polymer (III) of I with II was synthesized in a THF solution at 50° by UV irradiation or using radical initiators. The number-average mol. weight of the insoluble III in THF was about 20000-30000 and the soluble was about 4000. Based on the S content and IR spectrum of the insoluble III, the obtained III had an alternating structure consisting of I and II units. X-ray patterns indicate that the polymer has a layered structure. The conductivity of undoped III was 10^-11 S/cm, but increased to 10^-6 S/cm by doping with iodine.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, HPLC of Formula: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shureiqi, Imad published the artcileThe 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells, Quality Control of 59973-80-7, the publication is Proceedings of the National Academy of Sciences of the United States of America (2003), 100(17), 9968-9973, database is CAplus and MEDLINE.

Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which is the primary product of 15-LOX-1 metabolism of linoleic acid, restores apoptosis. Nonsteroidal antiinflammatory drugs (NSAIDs) transcriptionally up-regulate 15-LOX-1 expression to induce apoptosis. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for linoleic and arachidonic acid metabolites. PPAR-δ promotes colonic tumorigenesis. NSAIDs suppress PPAR-δ activity in colon cancer cells. The mechanistic relationship between 15-LOX-1 and PPAR-δ was previously unknown. Our current study shows that. (i) 13-S-HODE binds to PPAR-δ, decreases PPAR-δ activation, and down-regulates PPAR-δ expression in colorectal cancer cells;. (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-δ and the resultant induction of apoptosis; and. (iii) PPAR-δ is an important signaling receptor for 13-S-HODE-induced apoptosis. The in vivo relevance of these mechanistic findings was demonstrated in our tumorigenesis studies in nude mouse xenograft models. Our findings indicate that the down-regulation of PPAR-δ by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C3H9ClOS, Quality Control of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wong, Benjamin Chun-Yu published the artcileCyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase, Product Details of C20H17FO4S, the publication is Gastroenterology (2004), 126(1), 136-147, database is CAplus and MEDLINE.

Background & Aims: Aspirin exerts antitumor effect partly through blocking tumor promoter-induced activator protein-1 (AP-1) activation. The aim of this study is to determine how specific COX-2 inhibitor SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway. Methods: AP-1 transcriptional activity and DNA-binding activity were detected by luciferase reporter assay and gel shift assay, sep. Mitogen-activated protein kinase (MAPK) activation was determined by Western blot and in vitro kinase assay. Antisense oligonucleotide against c-Jun-N-terminal kinase (JNK) was used to suppress JNK expression. Results: We showed that SC-236 inhibited 12-O-tetradecanoylphorbol-13-acetate (PMA)-induced cell transformation in a dose-dependent manner in JB6 cells. At a dose range (12.5-50 μmol/L) that inhibited cell transformation, SC-236 also inhibited anchorage-independent cell growth and AP-1-activation in 3 gastric cancer cells, independent of COX-prostaglandin synthesis. SC-236 down-regulated c-Jun-NH2-terminal kinase phosphorylation and activity. Suppression of JNK activity reversed the inhibitory effect on AP-1 activity by SC-236 and suppressed gastric cancer cell growth, indicating that the inhibitory effect of SC-236 on AP-1 activation and cell growth was through interaction with JNK. Conclusions: The inhibitory effect on JNK-c-Jun/AP-1 activation contributes to the antitumor effect of COX-2-specific inhibitor, and inhibition of JNK activation may have a therapeutic benefit against gastric cancer.

Gastroenterology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C7H16N2, Product Details of C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem