Category: naphthyridines

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 149022-15-1, Name is 3-Methyl-2-benzothiazolinone hydrazone hydrochloride hydrate(1:1:x), formurla is C8H12ClN3OS. In a document, author is de Morais Oliveira-Tintino, Cicera Datiane, introducing its new discovery. Formula: C8H12ClN3OS.

Do 1,8-naphthyridine sulfonamides possess an inhibitory action against Tet (K) and MsrA efflux pumps in multiresistant Staphylococcus aureus strains?

Naphthyridines represent a class of heterocyclic compounds formed by two condensed aromatic rings. This study aimed to evaluate the antibacterial activity and in vitro inhibition of efflux resistance mechanisms of a series of 1,8-naphthyridine sulfonamides against strains carrying Tet(K) and MsrA efflux pumps. The efflux pump inhibitory capacity was evaluated by analyzing synergistic effects between 1,8-naphthyridine sulfonamides and standard antibiotics, as well as ethidium bromide. The following 1,8-naphthyridines were used: 4-methyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 1); 2,5-Dichloro N (5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 2); 2,3,4-trifluoro-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 7); 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 9). The 1,8-naphthyridine sulfonamide derivatives possessed a potential Tet(K) and MsrA efflux pump inhibitory action.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

In an article, author is Melzer, Benedikt C., once mentioned the application of 754-05-2, Name is Trimethyl(vinyl)silane, molecular formula is C5H12Si, molecular weight is 100.2343, MDL number is MFCD00008606, category is naphthyridines. Now introduce a scientific discovery about this category, Recommanded Product: 754-05-2.

Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids

Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl center dot LiCl at -40 degrees C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and analogues thereof. In combination with a Parham-type cyclization a novel approach to pyrido[4,3,2-mn]acridones has been worked out.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, COA of Formula: C6H17NO3Si13822-56-5, Name is 3-(Trimethoxysilyl)propan-1-amine, SMILES is NCCC[Si](OC)(OC)OC, belongs to naphthyridines compound. In a article, author is Bandi, Madhu, introduce new discover of the category.

Diversity-oriented Multicomponent Synthesis of Bisquinolones under Green Conditions

A diversity-oriented green and eco-friendly synthesis of bisquinolones have been developed by simply condensation of N-methylquinolone (1), with various benzaldehydes 2a-n and aniline (3) under catalyst-free conditions. An exciting feature of this communication is the product formation that depends on the intermediate (II) generated in the reaction mechanism.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Safety of 3-Hydroxy-2-naphthoic acid, 92-70-6, Name is 3-Hydroxy-2-naphthoic acid, SMILES is C1=C2C(=CC(=C1C(O)=O)O)C=CC=C2, belongs to naphthyridines compound. In a document, author is Dhar, Arghya K., introduce the new discover.

Design, Synthesis, and Pharmacological Evaluation of Novel 2-(4-substituted piperazin-1-yl)1, 8 Naphthyridine 3-Carboxylic Acids as 5-HT3 Receptor Antagonists for the Management of Depression

1, 8-naphthyridine-3-carboxylic acid analogs were synthesized and found to possess potential 5-HT3 receptor antagonism as well as antidepressant-like activity. Initially, 5-HT3 receptor antagonism of all the compounds was determined in the form of pA(2) value against agonist 2-methyl 5-HT in longitudinal muscle-myenteric plexus preparation from guinea-pig ileum. Among all the compounds tested, compound 7a demonstrated most promising pA(2) value of 7.6. Subsequently, all the compounds were evaluated for antidepressant activity using forced swim test and tail suspension test in mice. Compounds 7a, 7d, 7f, 7h, and 7i exhibited significant (p<0.05) antidepressant-like activity as compound to vehicle-treated group. Importantly, none of the tested compound affected locomotor activity of mice at tested dose levels. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 92-70-6. Safety of 3-Hydroxy-2-naphthoic acid.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 61-19-8, Name is Adenosine 5′-monophosphate, SMILES is O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(O)=O, belongs to naphthyridines compound. In a document, author is Dante, Roberto C., introduce the new discover, Product Details of 61-19-8.

Nitrogen-carbon graphite-like semiconductor synthesized from uric acid

A new carbon-nitrogen organic semiconductor has been synthesized by pyrolysis of uric acid. This layered carbon-nitrogen material contains imidazole-, pyridine (naphthyridine)-and graphitic-like nitrogen, as evinced by infrared and X-ray photoelectron spectroscopies. Quantum chemistry calculations support that it would consist of a 2D polymeric material held together by hydrogen bonds. Layers are stacked with an interplanar distance between 3.30 and 3.36 angstrom, as in graphite and coke. Terahertz spectroscopy shows a behavior similar to that of amorphous carbons, such as coke, with non-interacting layers. This material features substantial differences from polymeric carbon nitride, with some characteristics closer to those of nitrogen-doped graphene, in spite of its higher nitrogen content. The direct optical band gap, dependent on the polycondensation temperature, ranges from 2.10 to 2.32 eV. Although in general the degree of crystallinity is low, in the material synthesized at 600 C-circle some spots with a certain degree of crystallinity can be found. (C) 2017 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 61-19-8 is helpful to your research. Product Details of 61-19-8.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

89-63-4, Name is 4-Chloro-2-nitroaniline, molecular formula is C6H5ClN2O2, belongs to naphthyridines compound, is a common compound. In a patnet, author is Wang, Shuxin, once mentioned the new application about 89-63-4, Product Details of 89-63-4.

Tunable Luminescence in Hybrid Cu(I) and Ag(I) Iodides

Hybrid materials are increasingly demonstrating their utility across several optical, electrical, and magnetic applications. Cu(I) halide-based hybrids have attracted attention due to their strong luminescence in the absence of rare-earths. Here, we report three Cu(I) and Ag(I) hybrid iodides with 1,5-naphthyridine and additional triphenylphosphine (Ph3P) ligands. The compounds are built on (Cu/Ag)-I staircase chains or on a rhomboid Cu2I2 dimer and display intense and tunable luminescence. Replacing Cu with Ag, and adding the second kind of organic ligand (Ph3P) tunes the emission color from red to yellow and results in significantly enhanced quantum yield. Density functional theory-based electronic structure calculations reveal the separate effects of the inorganic module and organic ligand on the electronic structure, confirming that bandgap, optical absorption, and emission properties of these phosphors can be systemically and deliberately tuned by metal substitution and organic ligands cooperation. The emerging understanding of composition-structure-property relations in this family provides powerful design tools toward new compounds for general lighting applications.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Formula: C9H7F3O, begins with the direct observation of nature¡ª in this case, of matter.709-63-7, Name is 4-(Trifluoromethyl)acetophenone, SMILES is C1=C(C=CC(=C1)C(C)=O)C(F)(F)F, belongs to naphthyridines compound. In a document, author is Gan, Xin, introduce the new discover.

Cu(I) and Pb(II) complexes containing new tris(7-naphthyridyl)methane derivatives: Synthesis, structures, spectroscopy and geometric conversion

Two novel facial-capping tris-naphthyridyl compounds, 2-chloro-5-methyl-7-((2,4-dimethyl-1,8-naphthyridin-7(1H)-ylidene)(2,4-dimethyl-1,8-naphthyridin-7-yl))methyl-1,8-naphthyridine (L-1) and 2-chloro-7-((2-methyl-1,8-naphthyridin-7(1H)-ylidene)(2-methyl-1,8-naphthyridin-7-yl)) methyl-1,8-naphthyridine (L-2), as well as their Cu(I) and Pb(II) complexes, [CuLa(PPh3)]BF4 (1) (PPh3 = triphenylphosphine, L-a = bis(2,4-dimethyl-1,8-naphthyridin-7-yl)(2-chloro-5-methyl-1,8-naphthyridin-7-yl)methane), [CuLb(PPh3)]BF4 (2) (L-b = bis(2-methyl-1,8-naphthyridin-7-yl)(2-chloro-1,8-naphthyridin-7-yl)methane), [Pb(OLa)(NO3)(2)] (3) (OLa = bis(2,4-dimethyl-1,8-naphthyridin-7-yl)(2-chloro-5-methyl-1,8-naphthyridin-7-yl)methanol) and [Pb(L-b)(2)][Pb(CH3OH)(NO3)(4)] (4), have been synthesized and characterized by X-ray diffraction analysis, MS, NMR and elemental analysis. The structural investigations revealed that the transfer of the H-atom at the central carbon to an adjacent naphthyridine-N atom affords L-1 and L-2 possessing large conjugated architectures, and the central carbon atoms adopt the sp(2) hybridized bonding mode. The reversible hydrogen transfer and a geometric configuration conversion from sp(2) to sp(3) of the central carbon atom were observed when Pb(II) and Cu(I) were coordinated to L-1 or L-2. The molecular energy changes accompanying the hydrogen migration and titration of H+ to different receptor-N at L-1 were calculated by density functional theory (DFT) at the SCRF-B3LYP/6-311++G(d,p) level in a CH2Cl2 solution, and the observed lowest-energy absorption and emission for L-1 and L-2 can be tentatively assigned to an intramolecular charge transfer (ICT) transition in nature.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16415-12-6, Name is Hexadecyltrimethoxysilane, molecular formula is C19H42O3Si, belongs to naphthyridines compound. In a document, author is Chaitanya, Muggu V. S. R. K., introduce the new discover, Recommanded Product: Hexadecyltrimethoxysilane.

A Rapid and Convenient Synthesis of Naphthyridinoyl Pyrazolidinones under Microwave Irradiation Condition

Microwave-assisted synthesis of naphthyridinoylpyrazolidinones (7a-7j) has been achieved rapidly via the reaction of naphthyridine hydrazide (4) with different beta-keto esters and ethoxymethylenemalonic ester (EMME) (5a-5e). Initially, the reaction of naphthyridine hydrazide (4) with various beta-keto esters under microwave irradiation for 5 mins at 130 degrees C results in the formation of condensed products 6a-6j. This condensation was followed by cyclization, also, in diphenyl ether under microwave irradiation for 10 mins at 230-250 degrees C, yielding the corresponding cyclized products 7a-7j. Alternatively, both reactants 4 and each of the beta-keto esters/EMME (5a-5e) were treated in diphenyl ether under microwave irradiation for 15 mins at 230-250 degrees C giving the target molecules 7a-7j as one-pot reaction in good yields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 16415-12-6. Recommanded Product: Hexadecyltrimethoxysilane.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

In an article, author is Czapik, Agnieszka, once mentioned the application of 553-97-9, HPLC of Formula: C7H6O2, Name is 2-Methylcyclohexa-2,5-diene-1,4-dione, molecular formula is C7H6O2, molecular weight is 122.1213, MDL number is MFCD00001603, category is naphthyridines. Now introduce a scientific discovery about this category.

Chiral Cocrystal Solid Solutions, Molecular Complexes, and Salts of N-Triphenylacetyl-L-Tyrosine and Diamines

The molecular recognition process and the ability to form multicomponent supramolecular systems have been investigated for the amide of triphenylacetic acid and L-tyrosine (N-triphenylacetyl-L-tyrosine, TrCOTyr). The presence of several supramolecular synthons within the same amide molecule allows the formation of various multicomponent crystals, where TrCOTyr serves as a chiral host. Isostructural crystals of solvates with methanol and ethanol and a series of binary crystalline molecular complexes with selected organic diamines (1,5-naphthyridine, quinoxaline, 4,40-bipyridyl, and DABCO) were obtained. The structures of the crystals were planned based on non-covalent interactions (O-H center dot center dot center dot N or N-H+center dot center dot center dot O- hydrogen bonds) present in a basic structural motif, which is a heterotrimeric building block consisting of two molecules of the host and one molecule of the guest. The complex of TrCOTyr with DABCO is an exception. The anionic dimers built off the TrCOTyr molecules form a supramolecular gutter, with trityl groups located on the edge and filled by DABCO cationic dimers. Whereas most of the racemic mixtures crystallize as racemic crystals or as conglomerates, the additional tests carried out for racemic N-triphenylacetyl-tyrosine (rac-TrCOTyr) showed that the compound crystallizes as a solid solution of enantiomers.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Related Products of 38002-45-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 38002-45-8, Name is (3-Bromoprop-1-yn-1-yl)trimethylsilane, SMILES is C[Si](C)(C#CCBr)C, belongs to naphthyridines compound. In a article, author is Luo, Wenxiu, introduce new discover of the category.

Fluorescent Zn-II Chemosensor Mediated by a 1,8-Naphthyridine Derivative and Its Photophysical Properties

One of the greatest challenges in using fluorescent chemosensors for highly selective and sensitive transition-metal ions is finding an efficient and simple method for its synthesis. In this study, a highly efficient fluorescence chemosensor for Zn-II was developed from N-Boc-L-proline modified 1,8-naphthyridine. The fluorescence intensity of the chemosensor was increased significantly only in the presence of Zn-II ion which provided a perceived color change for rapid visual sensing, while other metal ions showed fluorescence quenching or little changes. It was worth noting that the chemosensor L distinguished Zn-II from Cd-II commonly having similar properties. The solvent effect and possible bonding mode for fluorescence enhancement have been also discussed. Results of this study indicated that the Boc-group in L-proline significantly improved the sensitivity and selectivity for Zn-II detection performance, as confirmed by comparison experiments and time dependent-density functional theory (TD-DFT) calculations.

Related Products of 38002-45-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 38002-45-8.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem