Category: naphthyridines

In an article, author is Moustafa, Moustafa Sherief, once mentioned the application of 99-09-2, Name is 3-Nitroaniline, molecular formula is C6H6N2O2, molecular weight is 138.124, MDL number is MFCD00007782, category is naphthyridines. Now introduce a scientific discovery about this category, Product Details of 99-09-2.

Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines

Reaction of enaminones 1a-d with 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2) in the presence of AcOH/NH4OAc afforded 7-amino-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbonitrile derivatives 9a-d. On the other hand, 2-aminopyrano[4,3,2-de][1,6]naphthyridine-3-carbonitriles 20a-c,e were the only obtained products from the reactions of 1a-d with 2 in the presence of AcOH/NaOAc, while 1d afforded [3,5-bis-(4-chloro-benzoyl)-phenyl]-(4-chloro-phenyl)-methanone 21 under the same condition. The reaction of 2 with diethyl acetylenedicarboxylate in the presence of AcOH/NH4OAc afforded (4-cyano-5-dicyanomethylene-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid ethyl ester 15B.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 82-76-8, Name is 8-(Phenylamino)naphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C(NC3=CC=CC=C3)=CC=CC2=CC=C1)(O)=O, in an article , author is Hossaini, Zinatossadat, once mentioned of 82-76-8, Quality Control of 8-(Phenylamino)naphthalene-1-sulfonic acid.

ZnO/Ag/Fe3O4 nanoparticles supported on carbon nanotubes employing Petasites hybridus rhizome water extract: A novel organometallic nanocatalyst for the synthesis of new naphthyridines

In this study, ZnO/Ag/Fe3O4/CNTs nanoparticles (NPs) immobilized on carbon nanotubes (ZnO/Ag/Fe3O4/CNTs) were synthesized using Petasites hybridus rhizome water extract as a renewable, mild, and safe reducing agent and effective stabilizer without adding any surfactants. For the confirmation of the structure of the green synthesized NPs, various methods such as X-ray diffraction (XRD), FESEM, transmission electron microscopy (TEM), Energy-Dispersive X-Ray Spectroscopy (EDS), and Vibrating Sample Magnetometer (VSM) were employed. The ZnO/Ag/Fe3O4/CNTs magnetic NPs as a high performance catalyst was employed for the preparation of naphthyridine derivatives in high yields via the multicomponent reactions of phthalaldehyde, 2-aminoactonitrile, activated acetylenic compounds, alpha-haloketones, triphenyphophine, and ammonium acetate in aqueous media at ambient temperature. Due to having isoquinoline core, we investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Furthermore, the disk diffusion test on Gram-positive and Gram-negative bacteria IS utilized for investigation of antimicrobial activity of some naphthyridines. The achieved outcomes of this experiment demonstrate that these synthesized compounds could prevent from growth of bacteria. Short time of reaction, high yields of product, easy separation of catalyst, and products are some benefits of this process.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

82-76-8, Name is 8-(Phenylamino)naphthalene-1-sulfonic acid, molecular formula is C16H13NO3S, Safety of 8-(Phenylamino)naphthalene-1-sulfonic acid, belongs to naphthyridines compound, is a common compound. In a patnet, author is Horrillo, Igor, once mentioned the new application about 82-76-8.

Chronic fluoxetine reverses the effects of chronic corticosterone treatment on alpha(2)-adrenoceptors in the rat frontal cortex but not locus coeruleus

Disruption of the hypothalamic-pituitary-adrenal axis is an established finding in patients with anxiety and/or depression. Chronic corticosterone administration in animals has been proposed as a model for the study of these stress-related disorders and the antidepressant action. Alterations of the central noradrenergic system and specifically of inhibitory alpha(2)-adrenoceptors seem to be part of the pathophysiology of depression and contribute to the antidepressant activity. The present study evaluates in male rats the effect of chronic corticosterone treatment during 35 days (16-20 mg kg(-1) day(-1)) on the sensitivity of alpha(2)-adrenoceptors expressed in the somatodendritic and terminal noradrenergic areas locus coeruleus (LC) and prefrontal cortex (PFC), respectively. Further, the effect of chronic fluoxetine treatment (5 mg kg(-1), i.p., since the 15th day) on the sensitivity of alpha(2)-adrenoceptors was examined under control conditions and in corticosterone-treated rats. The alpha(2)-adrenoceptor functionality was analysed in vitro by agonist-mediated [S-35]GTP gamma S binding stimulation and in vivo through the modulation of noradrenaline (NA) release evaluated by dual-probe microdialysis. The concentration-effect curves of the [S-35]GTP gamma S binding stimulation by the agonist UK14304 (5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine) demonstrated a desensitization of cortical alpha(2)-adrenoceptors induced by corticosterone (-logEC(50) = 6.7 +/- 0.2 vs 8.2 +/- 0.3 in controls) that was reverted by fluoxetine treatment (-logEC(50) = 7.5 +/- 0.3). Local administration of the alpha(2)-adrenoceptor antagonist RS79948 ((8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(ethylsulfonyI)-6H-isoquino [2,1 -g] [1,6]naphthyridine) (0.1-100 mu mol L-1) into the LC induced a concentration-dependent NA increase in the PFC of the control group (E-max = 191 +/- 30%) but non-significant effect was observed in corticosterone-treated rats (E-max = 133 +/- 46%), reflecting a desensitization of a 2 -adrenoceptors that control the firing of noradrenergic neurons. Fluoxetine treatment did not alter the corticosterone-induced desensitization in this area (E-max = 136 +/- 19%). No effect of fluoxetine on alpha(2)-adrenoceptor functionality was observed in control animals (E-max = 223 +/- 30%). In PFC, the local administration of RS79948 increased NA in controls (E-max = 226 +/- 27%) without effect in the corticosterone group (E-max = 115 +/- 26%), suggesting a corticosterone-induced desensitization of terminal alpha(2)-adrenoceptors. Fluoxetine administration prevented the desensitization induced by corticosterone in the PFC (E-max = 233 +/- 33%) whereas desensitized alpha(2)-adrenoceptors in control animals (E-max = -24 +/- 10%). These data indicate that chronic corticosterone increases noradrenergic activity by acting at different alpha(2)-adrenoceptor subpopulations. Treatment with the antidepressant fluoxetine seems to counteract these changes by acting mainly on presynaptic alpha(2)-adrenoceptors expressed in terminal areas.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 132-64-9, Name is Dibenzo[b,d]furan, molecular formula is C12H8O. In an article, author is Matveeva, Anna G.,once mentioned of 132-64-9, Recommanded Product: Dibenzo[b,d]furan.

Lanthanide(III) complexes with phosphoryl containing 1,8-naphthyridine: Crystal structures and vibrational spectra

The complexes of 2-[2-(diphenylphosphoryl)prop-2-yl]-1,8-naphthyridine (L) with lanthanide nitrates Ln(NO3)(3) (Ln = Nd, Eu, Lu) were investigated to elucidate the coordination ability of a novel type of potentially tridentate ligands – phosphorylalkyl substituted naphthyridines. The X-ray crystal structures of [NdL3](3+) center dot 3(NO3) center dot MeCN (1), [EuL3](3+) center dot 3(NO3) center dot [Eu(NO3)(3) center dot 4H(2)O] center dot MeCN (2), and [LuL3](3+) center dot 3(NO3) center dot [Lu(NO3)(3) center dot 3H(2)O] center dot 2 MeCN center dot 0.5 H2O (3) are reported together with their IR and Raman spectra. All the compounds studied contain isostructural [LnL(3)](3+) cations and three NO3 counterions. Coordination of each L appears to be O, N, N tridentate-cyclic and coordination number of Ln is nine. Vibrational spectra of 1-3 are also compared with that of free ligand and model compounds. (C) 2009 Elsevier B. V. All rights reserved.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 6165-69-1, Name is 3-Thiopheneboronic acid. In a document, author is Li, Zhanxian, introducing its new discovery. Recommanded Product: 6165-69-1.

A switching on fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells

A highly sensitive and selective 1,8-naphthyridine-based fluorescent chemodosimeter for Zn2+ has been designed, synthesized, and applied to the detection of intracellular Zn2+.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: naphthyridines, 1631-25-0, Name is N-Cyclohexylmaleimide, molecular formula is C10H13NO2, belongs to naphthyridines compound. In a document, author is Hussein, Mahmoud A., introduce the new discover.

New heteroaromatic polyazomethines containing naphthyridine moieties: Synthesis, characterization, and biological screening

A new series of heteroaromatic polyazomethines containing 1,8-naphthyridine moieties in the polymer backbone were synthesized with a solution polycondensation technique. A new heteroaromatic monomer containing 1,8-naphthyridine moieties (4-ethoxy-2,7-dicarboxaldehyde-1,8-naphthyridine) was synthesized with an analogous synthetic sequence and confirmed by elemental and spectral data. The resulting polymers were characterized by elemental, spectral analyses, solubility and viscometry measurements. All the synthesized polyazomethines had better solubility in polar aportic solvents. The thermal properties of those polymers were evaluated by thermogravimetric analysis, differential thermogravimetry, and differential thermal analysis measurements and correlated to their structural units. All the polymers had nearly similar maximum polymer decomposition temperatures, which were in the range 557-577 degrees C. A very large difference between the glass transitions (92-222 degrees C) was observed. In addition, with gel permeation chromatography, the molecular weight determination of selected examples of those polymers was evaluated. The values of the average molecular weight for polyazomethines 7b and 7c were 34,914 and 24,859, respectively. On the other hand, the biological screening of all of the synthesized polyazomethines was performed in variety of bacteria and fungi. Most of the polyazomethines showed a significant influence against Gram-negative bacteria. The minimum inhibitory concentration of the most active polymers was 0.05 mg/mL.(C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1631-25-0. Category: naphthyridines.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 573-17-1, Name is 9-Bromophenanthrene, SMILES is BrC1=CC2=CC=CC=C2C2=C1C=CC=C2, in an article , author is Naik, Tangali R. Ravikumar, once mentioned of 573-17-1, HPLC of Formula: C14H9Br.

Synthesis of thieno[2,3-b]benzo[1,8]naphthyridine-2-carboxylic acids under microwave irradiation and interaction with DNA studies

The microwave-enhanced synthesis of 2-chloro-3-formylbenzo[1,8]naphthyridines 3a-c has been achieved rapidly in good yield via the Vilsmeier-Haack cyclisation of N-(4-methylquinolin-2yl) acetamide 2a-d. The precursors N-(4-methylquinolin-2-yl) acetamide derivatives were effectively prepared in a single step from 2-aminoquinoline and acetic anhydride in presence of Amberlite-120A cation exchange catalyst under microwave irradiation. Condensation of 3a-d, with thioglycolic acid under microwave irradiation using anhydrous potassium carbonate as catalyst afforded thieno[2,3-b]benzo[1,8]naphthyridine-2-carboxylic acids (TBNCS) 4a-g. Elemental analysis, IR, H-1 NMR, and mass spectral studies were used to characterize these compounds. The interaction of thieno[2,3-b] benzo[1,8]naphthyridine-2-carboxylic acid (TBNC)(4a) with CT-DNA was studied by UV-Vis, viscosity as well as thermal denaturation methods. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. Binding parameters, determined from spectrophotometeric measurements indicated a binding constant of 1.8 X 10(6) M-1. The thieno[2,3-b]benzo[1,8] naphthyridine-2-carboxylic acid (4a) increases the viscosity of sonicated rod- like DNA fragments. The binding of TBNC to DNA increased the melting temperature by about 4 degrees C. DNA interaction studies suggest that (4a) binds to calf thymus DNA (CT-DNA).

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 3-Hydroxy-2-naphthoic acid92-70-6, Name is 3-Hydroxy-2-naphthoic acid, SMILES is C1=C2C(=CC(=C1C(O)=O)O)C=CC=C2, belongs to naphthyridines compound. In a article, author is Wang, Kunyan, introduce new discover of the category.

1,5-Bis[(2-methoxyethoxy)methyl]-1,5-naphthyridine-4,8(1H,5H)-dione

The complete molecule of the title compound, C16H22N2O6, is generated by crystallographic inversion symmetry. The conformation of the N-C-O-C fragment of the side chain is approximately gauche [torsion angle = -74.84 (17)degrees]. In the crystal, weak C-H center dot center dot center dot O interactions link the molecules.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 6165-69-1, Name is 3-Thiopheneboronic acid, formurla is C4H5BO2S. In a document, author is Shaabani, Ahmad, introducing its new discovery. Name: 3-Thiopheneboronic acid.

A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides

A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described. (C) 2009 Published by Elsevier Ltd.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hirama, Yasuyuki, once mentioned the application of 709-63-7, Name is 4-(Trifluoromethyl)acetophenone, molecular formula is C9H7F3O, molecular weight is 188.15, MDL number is MFCD00000401, category is naphthyridines. Now introduce a scientific discovery about this category, Category: naphthyridines.

Synthesis and characterization of oligodeoxynucleotides containing a novel tetraazabenzo[cd]azulene:naphthyridine base pair

The synthesis and thermal stability of oligodeoxynucleotides (ODNs) containing 4-amino-2,3,5,6-tetraazabenzo[cd]azulen-7-one nucleosides 5 (BaON) with the aim of developing new base pairing motif is described. The tricyclic nucleoside 5 was prepared starting with the 7-deaza-7-iodopurine derivative 1 via a palladium catalyzed cross-coupling reaction with methyl acrylate, followed by an intramolecular cyclization. The resulting nucleoside was incorporated into ODNs, and the base pairing property of the BaON: NaNO (2-amino-7-hydroxy-1,8-naphthyridine nucleoside) pair in the duplex was evaluated by a thermal denaturation study. The melting temperature (T-m) of the duplex containing the BaON: NaNO pair showed a higher value than that of the duplexes containing the adenine: thymine (A:T) and the guanine: cytosine (G:C) pairs, however it was lower than that of the ImO(N): NaNO (ImO(N) = 7-amino-imidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidin-4(5H)-one nucleoside) pair. A temperature-dependent H-1 NMR study revealed that the H-bonding ability of BaON was lower than that of ImO(N), which would explain why the BaON: NaNO pair was less thermally stable than the ImO(N): NaNO pair. (C) 2010 Elsevier Ltd. All rights reserved.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem