Heterocyclic Building Blocks-Naphthyridine

Wu, Fang-Ying published the artcileA dual colorimetric and fluorescent sensor for lead ion based on naphthalene hydrazone derivative, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2013), 221-225, database is CAplus and MEDLINE.

A new compound, 2-boronobenzaldehyde-(2′-hydroxyl-4′-sulfonic acid) naphthalene hydrazone (1), was synthesized and its structure was characterized by ¹H NMR, mass and element analyses. The presence of Pb²⁺ led 1 to undergo colorimetric and fluorescent changes, which were detectable with the naked eye. Thus, a dual spectral response for Pb²⁺ detection was introduced. In KH₂PO₄-NaOH buffer aqueous solution (pH 6.0), 1 exhibited fluorescence enhancement at 568 nm and hyperchromicity at 595 nm upon the addition of Pb²⁺. The fluorescent intensity change was proportionate to the concentration of Pb²⁺ with a dynamic working range of 5.0 × 10^-7 mol L^-1 to 1.0 × 10^-4 mol L^-1 and a detection limit of 3.7 × 10^-8 mol L^-1. The fluorometric method was successfully applied for the detection of Pb²⁺ water of Qianhu Lake and soil in Nanchang university campus. The recoveries were 111-116% for water and 97.6% for soil, resp., determined via the standard addition method.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H10O2, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Jin published the artcileCharge trapping in the films blended with polystyrene and different cyano-substituted spirofluorenes organic small molecules, HPLC of Formula: 159-62-6, the publication is Applied Physics A: Materials Science & Processing (2020), 126(6), 451, database is CAplus.

We investigated the charges trapping and retention processes of the blend electret films of polystyrene and different cyano-substituted spirofluorenes organic small mol. material (PS/SFXs) by using at. force microscopy and Kelvin probe force microscopy technologies. The series of blend films present a promising charge storage property and a potential application in the charge trapping memory devices. We focused on the influences of the prepared parameters and the storage conditions for the samples on their charge storage properties. We found that water mols. in the films will influence the injection and retention processes of the trapped charges in the blend PS/SFXs films. The enhanced localization ability of the trapped charges is observed in the film prepared with high annealing temperature The thicknesses of the films have an obvious effect on the charge injection process while having no discernible effect on the retention process. These results are very important for the studies of PS/SFXs in memory devices. The results show that the polarization and net charge transfer coexist for charge trapping in PS/SFXs films, while the symmetry of mol. structure of SFXs plays an important role in trapped charges stability.

Applied Physics A: Materials Science & Processing published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C15H15OP, HPLC of Formula: 159-62-6.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sun, Ming-Li published the artcileDimeric SFX host materials for red, green and blue phosphorescent organic light-emitting devices, Name: Spiro[fluorene-9,9′-xanthene], the publication is Synthetic Metals (2014), 321-327, database is CAplus.

Two novel spiro[fluorene-9,9′-xanthene]-based derivatives 23’ODSFX and 3’3’ODSFX, without possessing conventional hole- or electron-transporting units, have been synthesized by a simple reaction procedure and been demonstrated to be host materials for efficient and low-voltage blue, green and red phosphorescent organic light-emitting devices (PHOLEDs). They showed good thermal stability with high glass transition temperatures (T_g) at 210 °C for 23’ODSFX and 138 °C for 3’3’ODSFX. Compared with SFX-based devices, the performance of 23’ODSFX-based devices increased nearly 20 times, although the difference of HOMO/LUMO levels and triplet levels between dimeric SFX and SFX was very small. The blue PHOLEDs based on 23’ODSFX and 3’3’ODSFX exhibited the same low turn-on voltage of ∼2.6 V, and maximum current efficiency (CE) of 21.7/12.9 cd cd A^-1, power efficiency (PE) of 19.5/11.5 lm W^-1, and external quantum efficiency (EQE) of 11.9%/7.2%, resp. It was evident that the different position linkage in host materials was closely relative to the device performance.

Synthetic Metals published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C19H21N3O3S, Name: Spiro[fluorene-9,9′-xanthene].

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Liu, Xiangguo published the artcileDeath Receptor Regulation and Celecoxib-Induced Apoptosis in Human Lung Cancer Cells, Name: Sulindac sulfone, the publication is Journal of the National Cancer Institute (2004), 96(23), 1769-1780, database is CAplus and MEDLINE.

Background: Celecoxib, a cyclooxygenase 2 inhibitor, has chemopreventive and therapeutic activities toward lung cancer and other epithelial malignancies. Celecoxib can induce apoptosis in various cancer cell lines through a mechanism that is independent of its cyclooxygenase 2 inhibitory activity but is otherwise largely uncharacterized. We investigated the mechanism of celecoxib-induced apoptosis further. Methods: All experiments were conducted in human non-small-cell lung carcinoma (NSCLC) cell lines; results in celecoxib-treated and untreated cells were compared. Cell survival was assessed with a sulforhodamine B assay. Apoptosis was assessed by DNA fragmentation with an ELISA, by terminal deoxynucleotidyltransferase-mediated dUTP nick-end-labeling (TUNEL) assay, and by western blot anal. of caspase activation. Death receptor gene and protein expression was detected by northern and western blot anal., resp. Gene silencing was achieved with small interfering RNA (siRNA) technol. Results: Celecoxib treatment decreased cell survival, activated caspase cascades, and increased DNA fragmentation, all of which were abrogated when caspase 8 expression was silenced with caspase 8 siRNA. Celecoxib treatment induced the expression of death receptors, particularly that of DR5. Overexpression of a dominant neg. Fas-associated death domain mutant, but not of BCL2, reduced the level of celecoxib-induced apoptosis, and silencing of DR5 expression by DR5 siRNA suppressed celecoxib-induced caspase 8 activation and apoptosis. Combination treatment with celecoxib and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced addnl. apoptosis. For example, survival of A549 cells was decreased with 50 μM celecoxib alone by 38.7% (95% confidence interval [CI] = 35.2% to 42.2%), with TRAIL alone by 29.3% (95% CI = 25.1% to 33.6%), but with their combination by 77.5% (95% CI = 74.5% to 79.5%), a greater than additive effect. Conclusion: Celecoxib appears to induce apoptosis in human NSCLC through the extrinsic death receptor pathway.

Journal of the National Cancer Institute published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Name: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhao, Zujin published the artcileNovel, yellow-emitting anthracene/fluorene oligomers: synthesis and characterization, Quality Control of 18512-55-5, the publication is Tetrahedron (2007), 63(33), 7809-7815, database is CAplus.

Five highly soluble and strongly yellow fluorescent oligoalkyne dyes with well-controlled, alternating anthracene and fluorene units were successfully synthesized by a Pd/Cu-catalyzed Sonogashira coupling reaction and characterized. Their thermal stabilities, electrochem. behaviors, and photophys. properties were investigated. These oligomers might be used as models to study structure-property relationship for their corresponding polymers and applied in optoelectronics devices as materials themselves.

Tetrahedron published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C21H37BO, Quality Control of 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhang, Chun-Hui published the artcileAn easily and environmentally friendly accessible small-molecule acetylenic donor for organic solar cells, Product Details of C18H10, the publication is Dyes and Pigments (2019), 983-988, database is CAplus.

Photovoltaic aryl acetylenes may provide a green access to high performance electron donors for organic solar cells. Here we describe a solution-processable acetylenic mol. An(DTDPPA)₂, which consists of a central anthracen-9,10-diyl unit and two dithienyldiketopyrrolopyrrole end-groups via acetylenic linkages. It’s worth noting that the acetylenic linkages in An(DTDPPA)₂ enable facile and green accessibility through Sonogashira reactions with atypically high yield and atom efficiency. In solid film An(DTDPPA)₂ features an absorption peak at 630 nm with an emerging shoulder at 686 nm. The HOMO/LUMO level of An(DTDPPA)₂ is estimated as -5.18/-3.62 eV according to cyclic voltammetry and the optical absorption onset. Due to the highly coplanar configuration and close packing, the hole mobility of the thermally annealed film of An(DTDPPA)₂ was improved to as high as 9.30 × 10^-4 cm² V^-1 s^-1. In combination with PC₆₁BM, the bulk heterojunction solar cells provide a power conversion efficiency of 5.26% utilizing no processing additive or solvent vapor annealing. The results are carefully discussed in comparison to the related compounds without the acetylenic linkage and based on the DFT mol. modeling. The demonstrated dramatic effects of acetylenic linkages in this work may encourage and motivate more efforts to design easily accessible and eco-friendly organic semiconductors.

Dyes and Pigments published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C19H14N2, Product Details of C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhu, Ming-Hui published the artcileDetosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides, Application In Synthesis of 2960-93-2, the publication is Organic Letters (2019), 21(17), 7073-7077, database is CAplus and MEDLINE.

An efficient strategy for N/O-(deutero)alkylation of indoles and phenols with alkoxides/alcs. as the alkylation reagents is described. The consecutive detosylation/alkylation transformations feature mild reaction conditions, high ipso-selectivity, and good functional group tolerance (>50 examples). A one-pot selective N-alkylation of unprotected indoles with alcs. and TsCl is also realized. The application of this method is demonstrated by the introduction of isotope-labeled (CD₃ and ¹³CH₃) groups using the readily accessible labeled alcs. and the synthesis of pharmaceuticals.

Organic Letters published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C7H5I2NO3, Application In Synthesis of 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yoshida, Kunio published the artcileLaser-induced damage of multilayer coated optical components, Application of 1-(Difluoromethyl)naphthalene, the publication is Kaku Yugo Kenkyu (1992), 68(Suppl.), 227-33, database is CAplus.

A number of optics having high quality and high damage threshold were developed. The damage threshold of borosilicate crown glass was considerably improved. The surface roughness dependence of the laser-induced surface damage of optical glasses and the laser-induced damage of HR coating were found for the first time. These optical technologies meet the GEKKO XII Upgrade fluence requirements.

Kaku Yugo Kenkyu published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C17H20ClN3, Application of 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Demchuk, Oleg M. published the artcileA mixed naphthyl-phenyl phosphine ligand motif for Suzuki, Heck, and hydrodehalogenation reactions, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Synlett (2006), 2908-2913, database is CAplus.

Nap-Phos, representing a new naphthyl-Ph biaryl-type phosphine ligand class and available by a short synthesis (4 steps, 71% overall yield), effectively catalyzes the Suzuki-Miyaura (including highly hindered cases), hydrodehalogenation, and Heck reactions.

Synlett published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Nogi, Keisuke published the artcileAromatic metamorphosis: conversion of an aromatic skeleton into a different ring system, Application of Spiro[fluorene-9,9′-xanthene], the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(29), 4055-4065, database is CAplus and MEDLINE.

Recent advances in the area of “aromatic metamorphosis”, where various aromatic compounds, such as dibenzothiophenes, dibenzofurans, and benzofurans, are transformed into a variety of ring systems using a multi-step strategy or ideally in one step has been reviewed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C25H16O, Application of Spiro[fluorene-9,9′-xanthene].

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem