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Related Products of 7689-62-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.7689-62-5, Name is 2-Chloro-1,5-naphthyridine, molecular formula is C8H5ClN2. In a article£¬once mentioned of 7689-62-5

Beijing Fulong Kangtai Biological Co., Ltd.; Ji Qi; Gao Congmin; Wang Lei; Gong Longlong; Chen Bo; Du Zhenjian

The invention belongs to the field, of medicines, particularly relates to Trk inhibitor, and a preparation method and application. thereof, and mainly relates to a compound A1, represented by Formula A2, or Formula A3 or a pharmaceutically acceptable salt A4 stereoisomer, isotope label, solvate, polymorph or prodrug, thereof, and a preparation method, and application of the compound. (by machine translation)

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1,468-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N462 – PubChem

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Yang, Zhen; Fathi, Reza; Zhu, Qiang; Cho, Hyun-Joon; Liu, Yixin; Sandrasagra, Anthony; Wobbe, C. Richard

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.

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1,506-Naphthyridine – Wikipedia,
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Friedlaender reactions of triacetylmethane with selected beta-amino-alpha,beta-unsaturated aldehydes afforded pyridoheterocycles and their 2-methyl derivatives instead of triheteroarylmethane.

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Manganese-catalyzed hydrogenation reactions have attracted broad interest since the first report in 2016. Among the reported catalytic systems, Mn catalysts supported by tridentate PNP- and NNP-pincer ligands have most commonly been used. For example, a number of PNP-Mn pincer catalysts have been reported for the hydrogenation of aldehydes, aldimines, ketones, nitriles, and esters. Furthermore, various NNP-Mn pincer catalysts have been shown to be active in the hydrogenation of less-reactive substrates such as amides, carbonates, carbamates, and urea derivations. These observations indicated that Mn catalysts supported by NNP-pincer ligands exhibit higher reactivity in hydrogenation reactions than their PNP counterparts. Such a ligand effect in Mn-catalyzed hydrogenation reactions has yet to be confirmed. Herein, we investigated the origin and applicability of this ligand effect. A combination of experimental and theoretical investigations showed that NNP-pincer ligands on the Mn complexes were more electron-rich and less sterically hindered than their PNP counterparts, leading to higher reactivity in a series of Mn-catalyzed hydrogenation reactions. Inspired by the ligand effect on Mn-catalyzed hydrogenations, we developed the first Mn-catalyzed hydrogenation of N-heterocycles. Specifically, NNP-Mn pincer catalysts hydrogenated a series of N-heterocycles (32 examples) with up to 99% yields, and the corresponding PNP-Mn pincer catalysts afforded low reactivity under the same conditions. This verified that such a ligand effect is generally applicable in hydrogenation reactions of both carbonyl and noncarbonyl substrates based on Mn catalysis.

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SMITHKLINE BEECHAM CORPORATION

Invented is a method of inhibiting the activity/function of PB kinases using naphthyridine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of naphthyridine derivatives.

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1,525-Naphthyridine – Wikipedia,
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3-Nitro and 3,6-dinitro-1,8-naphthyridines 1, 4 and 5 are dehydroaminated with a liquid ammonia solution of potassium permanganate to the corresponding 4-amino-substituted compounds 3, 8 and 9.The intermediate 4-amino ?-adducts 2,6 and 7 of the nitro-1,8-naphthyridines are detected by 1H-NMR spectroscopy.The syntheses of some nitro-substituted naphthyridines are described. Key Words: Amination / Amino ?-adducts / Naphthyridines

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1,471-Naphthyridine – Wikipedia,
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A naphthyridine-derived expanded pincer ligand is described that can host two copper(I) centers. The proton-responsive ligand can undergo reversible partial and full dearomatization of the naphthyridine core, which enables cooperative activation of H2 giving an unusual butterfly-shaped Cu4H2 complex.

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1,351-Naphthyridine – Wikipedia,
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Reaction of quinazoline with trimethylsilyl cyanide and benzoyl chloride gave 2,4-dicyano-1,3-dibenzoyl-1,2,3,4-tetrahydroquinazoline as the major product.This compound undergoes monoalkylation with methyl iodide in the presence of sodium hydride.Reaction of cinnoline with trimethylsilyl cyanide and benzoyl chloride gave 1,2-dibenzoyl-4-cyano-1,2-dihydrocinnoline.

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Oxidative additions of dichloromethanes to a diiridium(I) core, bridged by 2-ferrocenyl-1,8-naphthyridines (NP-Fc), provide an iridium(II) dimer, [IrCl2(CO)2(eta1-NP-Fc)]2, featuring an unsupported Ir-Ir single bond (2.7121(8) A). The Royal Society of Chemistry.

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1,364-Naphthyridine – Wikipedia,
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Merck & Co., Inc.

A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of alphav integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

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1,32-Naphthyridine – Wikipedia,
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