Tag: M.W:100-200

In an article, published in an article,authors is Basavaiah, Deevi, once mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene,molecular formula is C8H6N2, is a conventional compound. this article was the specific content is as follows. 254-60-4

This review describes, in brief, the philosophy, vision and long-term research experience of the senior author (DB) in the area of the Baylis-Hillman (BH) [also known as the Morita-Baylis-Hillman (MBH)] reaction. It presents a clear picture of how the senior author (DB) has (i) uncovered the BH reaction, which was actually buried in the literature, (ii) recognized its high level potential, and (iii) initiated a major research program, nurtured it, elegantly contributed to it, and popularized it from the concealed patent level to the present levels of powerful C-C bond forming reactions, attaining the status of a new continent in organic chemistry. While presenting mostly the contributions of our research group, this brief review also describes some of the important and relevant contributions from other research groups. This article clearly demonstrates the power of molecules containing three proximal functional groups and highlights the unending opportunities, and challenges offered by this fascinating reaction.

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1,56-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N50 – PubChem

254-60-4, An article , which mentions 254-60-4, molecular formula is C8H6N2. The compound – 1,8-Diazanaphthalene played an important role in people’s production and life.

Owing to their much more accessible structural diversity and recognition mechanism, the fluorescent probes with small molecular scaffold are significant, and they have been broadly investigated in the cutting edge of materials and biological chemistry. Known as the facile synthesis, expedient structural modification, good molecular stability, admirable fluorescence properties, multiple binding sites and excellent environmental compatibility, the benzazole moieties are under growing attraction in fluorescent probes for efficient detection of different species, such as cations (H+, Al3+, Hg2+, Cu2+, etc.), anions (HSO3 ?, F?, OH?, CN?, etc.), biomolecules (thiols, amino acids, etc.) and explosives (picric acid and TNT, etc.). In this review, benzimidazole-, benzoxazole- and benzothiazole-based fluorescent probes that have been reported in the recent three years (2017?2019) are refined to elucidate the progress of benzazole-based probes by combining their design strategy, synthetic route, sensing mechanism and applications. We wish that it may afford valuable recommendation to the construction of intelligent and versatile fluorescent probes based on benzazole derivatives.

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1,86-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N80 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO216,mainly used in chemical industry, its synthesis route is as follows.,1569-16-0

To a solution of 2-methyl-l,8-naphthyridine (2 g, 13.9 mmol) in ethanol (35mL) was added 10percent Pd/C, and the reaction mixture was stirred under H2 (10 psi) for 24 hours.Palladium was filtered out through celite and washed with excess ethanol. The filtrate wasconcentrated under vacuum to give 1.7 g (83percent) pink solid. NMR (CD3OD) 5 7.07 (d, 1H, J= 7.38 Hz), 6.32 (d, 1H, J = 7.25 Hz), 3.36-3.33 (m, 2H), 2.76-2.65 (m, 2H), 2.22 (s, 3H),25 1.87-1.82 (m, 2H). M+H=149.15.

With the complex challenges of chemical substances, we look forward to future research findings about 2-Methyl[1,8]-Naphthyridine,belong naphthyridine compound

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Patent; PHARMACIA CORPORATION; WO2005/51904; (2005); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO148,mainly used in chemical industry, its synthesis route is as follows.,7689-62-5

2-chloro-1,5-naphthyridine (101 mg, 0.614 mmol), boronate ester R1 (195 mg, 0.920 mmol), S-Phos (25.2 mg, 0.061 mmol), K3PO4 (391 mg, 1.841 mmol) and PdOAc2 (6.89 mg, 0.031 mmol) were combined in a 5-mL microwave vial in THF (2.5 mL) and water (500 mul). The reaction mixture was heated at 100 C for 15 min. The reaction mixture was diluted with EtOAc (20 mL), washed with sat. aq. NaHCO3 (25 mL) and brine (25 mL), dried over MgSO4 filtered, and concentrated in vacuo. The resulting residue was purified by gradient elution on silica gel (10 to 100% EtOAc in hexanes) to afford the title compound as a pale orange solid (118 mg, 90%). 1H NMR (500 MHz, DMSO): delta 9.02 (dd, J = 4.1, 1.6 Hz, 1 H), 8.48 (d, J = 8.8 Hz, 1 H), 8.48-8.42 (m, 1 H), 8.25 (d, J = 8.7 Hz, 1 H), 7.84-7.79 (m, 2 H), 7.13 (d, J = 16.0 Hz, 1 H), 4.25 (q, J = 7.1 Hz, 2 H), 1.30 (t, J = 7.1 Hz, 3 H) ppm; LRMS m/z (M+H) 229.2 found, 229.1 required.

With the complex challenges of chemical substances, we look forward to future research findings about 2-Chloro-1,5-naphthyridine,belong naphthyridine compound

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Patent; Merck Sharp & Dohme Corp.; BRESLIN, Michael J.; COX, Christopher D.; HARTINGH, Timothy J.; PERO, Joseph; RAHEEM, Izzat T.; ROSSI, Michael; VASSALLO, Laura; (89 pag.)EP2714041; (2016); B1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

Name is 2-Methyl[1,8]-Naphthyridine, as a common heterocyclic compound, it belongs to naphthyridine compound, and cas is 1569-16-0, its synthesis route is as follows.,1569-16-0

Int-19B. Ethyl (?)-4-(2-(l,8-naphthyridin-2-yl)vinyl)-lH-pyrrole-2-carboxylate: A solution of Int-19A (0.300 g, 2.08 mmol), commercially available ethyl 4-formyl-lH- pyrrole-2-carboxylate (0.348 g, 2.08 mmol), and 4-methylbenzenesulfonamide (0.356 g, 2.08 mmol) in toluene (4.5 mL) was stirred at reflux for 21 h. The precipitate was collected, triturated with DCM (2x) and the solid air-dried under vacuum to yield Int-19B (0.519 g, 94%) as a yellow solid. NMR (500 MHz, DMSO-c) delta 12.14 (br. s., 1H), (0504) 9.01 (dd, J = 4.3, 2.1 Hz, 1H), 8.41 – 8.28 (m, 2H), 7.82 (d, J = 16.2 Hz, 1H), 7.76 (d, J = 8.5 Hz, 1H), 7.52 (dd, J = 8.0, 4.1 Hz, 1H), 7.46 (s, 1H), 7.24 – 7.16 (m, 2H), 4.27 (q, J = (0505) 7.2 Hz, 2H), 1.31 (t, J= 7.0 Hz, 3H). HPLC retention time (Method 1): 1.973 mia; LCMS (ES): m/z 294.0 [M+H]+.

With the complex challenges of chemical substances, we look forward to future research findings about 2-Methyl[1,8]-Naphthyridine

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Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Guohua; MIGNONE, James; (117 pag.)WO2018/89360; (2018); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO195,mainly used in chemical industry, its synthesis route is as follows.,7689-62-5

2-chloro-l,5-naphthyridine (101 mg, 0.614 mmol), boronate ester XI (195 mg, 0.920 mmol), S-Phos (25.2 mg, 0.061 mmol), K3P04 (391 mg, 1.84 mmol) and PdOAc2 (6.89 mg, 0.031 mmol) were combined in a 5-mL microwave vial in THF (2.5 mL) and water (500 mu?). The reaction mixture was heated at 100 C for 15 min. The reaction mixture was diluted with EtOAc (20 mL), washed with sat. aq. NaHC03 (25 mL) and brine (25 mL), dried over MgS04, filtered, and concentrated in vacuo. The resulting residue was purified by gradient elution on silica gel (10 to 100% EtOAc in hexanes) to afford the title compound as a pale orange solid (118 mg, 90%). ‘H NMR (500 MHz, DMSO): delta 9.02 (dd, J = 4.1, 1.6 Hz, 1 H), 8.48 (d, J = 8.8 Hz, 1 H), 8.48-8.42 (m, 1 H), 8.25 (d, J = 8.7 Hz, 1 H), 7.84-7.79 (m, 2 H), 7.13 (d, J = 16.0 Hz, 1 H), 4.25 (q, J = 7.1 Hz, 2 H), 1.30 (t, J = 7.1 Hz, 3 H) ppm; LRMS m/z (M+H) 229.2 found, 229.1 required.

With the complex challenges of chemical substances, we look forward to future research findings about 2-Chloro-1,5-naphthyridine,belong naphthyridine compound

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Patent; MERCK SHARP & DOHME CORP.; COX, Christopher, D.; DUDKIN, Vadim; KERN, Jeffrey; LAYTON, Mark, E.; RAHEEM, Izzat, T.; WO2013/28590; (2013); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

249889-68-7, 8-Chloro-2-methoxy-1,5-naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 2-[2-methoxy-4-(6-methoxy-l55~naphthyridm-4-yloxy)phenyl]acetic acid used as a5 starting material was prepared as follows :; -Under an atmosphere of argon, a mixture of 4-chloro-6-methoxy-l,5-naphthyridine (0.97 g), tert-bvLtyl 2-(4-hydroxy-2-methoxyphenyl)acetate (1.19 g), caesium carbonate (3.26 g) and DMF (10 ml) was stirred and heated to 13O0C for 3.5 hours. The resultant mixture was cooled to ambient temperature and partitioned between ethyl acetate and water.I0 The organic phase was dried over magnesium sulphate and evaporated. The residue was purified by column chromatography on silica using increasingly polar mixtures of petroleum ether and ethyl acetate as eluent. There was thus obtained tert-bxxtyl 2-[2-methoxy- 4-(6-methoxy-l,5-naphthyridin-4-yloxy)phenyl]acetate (1.22 g); 1H NMR Spectrum: (DMSOd6) 1.41 (s, 9H)5 3.51 (s, 2H), 3.75 (s, 3H)5 3.94 (s, 3H)5 6.71 (m5 IH), 6.92 (m, 2H)5 is 7.24 (d5 IH)5 7.29 (d, IH)5 8.27 (d5 IH)5 8.61 (d, IH).

249889-68-7, As the paragraph descriping shows that 249889-68-7 is playing an increasingly important role.

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Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113548; (2007); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

7689-62-5, 2-Chloro-1,5-naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7689-62-5

Under Ar(g), to a mixture of pyrazin-2-amine (1) (209mg, 2.2mmol), 2- chloro-1 ,5-naphthyridine (2) (329mg, 2.0mmol), Cs2C03 (1.30g, 4.0mmol) was added degassed dry 1 ,4-dioxane (13ml_). The reaction mixture was then flushed with Ar(g) for 1 min before Pd2(dba)3 (92mg, 0.1 mmol) and Xantphos (127mg, 0.22mmol) were added. The reaction mixture was heated up to 90C for 40h. It was then cooled down to rt and concentrated in vacuo, CH2CI2 (15ml_) and H20 (15ml_) were added. The organic phase was separated and the water layer was extracted with EtOAc (15ml_). The organic layers were combined and Pd- scavenger (MP-TMT, ~400mg, 1.3mmol/g) was added. This was shaken for several hours followed by filtration. The filtrate was concentrated in vacuo, dissolved in DMSO (4ml_) and purified by basic prep LCMS to yield (3) as a solid (121 mg, 27%). (0160) LCMS (ES): Found 224.3 [M+Hf.

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Patent; KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; GATLAND, Alice Elizabeth; FINNEMORE, Daniel John; ALEXANDER, Rikki Peter; SILVA, Franck; CECIL, Alexander; (233 pag.)WO2019/166824; (2019); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 1,8-Naphthyridine-2-carboxylic acid, and cas is 215523-34-5, its synthesis route is as follows.,215523-34-5

600 mg (3.44 mmol) of 1,8-naphthyridine-2-carboxylic acid and 0.754 ml (10.3 mmol) of thionyl chloride were stirred in 15 ml of methanol at 60 C. for 6 h. The mixture was freed of the solvent under reduced pressure. Methyl tert-butyl ether was added to the residue and the mixture was freed of the solvent under reduced pressure. log P (neutral): 0.77; MH+: 189; 1H-NMR (400 MHz, CD3CN) delta ppm: 4.00 (s, 3H), 7.84 (dd, 1H), 8.27 (d, 1H), 8.70 (dd, 1H), 8.76 (d, 1H), 9.28 (m, 1H).

With the complex challenges of chemical substances, we look forward to future research findings about 215523-34-5,belong naphthyridine compound

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Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; FISCHER, Ruediger; HAGER, Dominik; HOFFMEISTER, Laura; KAUSCH-BUSIES, Nina; WILCKE, David; WILLOT, Matthieu; GOeRGENS, Urich; ILG, Kerstin; MOSRIN, Marc; PORTZ, Daniela; TURBERG, Andreas; US2018/305353; (2018); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

It is a common heterocyclic compound, the naphthyridine compound, 2,7-Naphthyridin-1-amine, cas is 27225-00-9 its synthesis route is as follows.,27225-00-9

4-Bromo-2,7-naphthyridin-1-ylamine32 g of 2,7-naphthyridin-1-ylamine is dissolved in 200 ml of acetic acid at room temperature. 35 g of bromine in 200 ml of acetic acid are then added slowly that the temperature does not exceed 25. The mixture is stirred for a further 60 minutes.The suspension obtained is dissolved in 500 ml of water, and the pH is adjusted to pH 7-8 using 500 ml of 25% aqueous ammonia solution.The mixture is stirred for 14 h. The brown precipitate is filtered off, washed with water and dried, giving 28.3 g of crude product. Purification by flash chromatography in ethyl acetate/methanol gives 18.5 g of 4-bromo-2,7-naphthyridin-1-ylamine, M224.06 g/mol, M+H found 224.

With the complex challenges of chemical substances, we look forward to future research findings about 2,7-Naphthyridin-1-amine

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Patent; Merck Patent GmbH; Jonczyk, Alfred; Zenke, Frank T.; Amendt, Christiane; US2015/252041; (2015); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem