Tag: M.W=200-250

Zhang, Yi-Qi published the artcileUnusual Deprotonated Alkynyl Hydrogen Bonding in Metal-Supported Hydrocarbon Assembly, COA of Formula: C18H10, the publication is Journal of Physical Chemistry C (2015), 119(17), 9669-9679, database is CAplus.

The authors demonstrate that terminal alkynyl moieties represent powerful functional groups for driving thermally stable, on-surface supramol. structure formation on a reactive substrate. Through a combination of scanning tunneling microscopy, XPS spectra, near-edge X-ray absorption-fine-structure spectra, and d. functional theory calculations, the mol.-surface interaction and self-assembly of two prototypical hydrocarbon species on Cu(111) were investigated. For 1,3,5-tris(4-ethynylphenyl)benzene (Ext-TEB) adsorption at low temperature (200 K) resulted in nonassembling, conformationally adapted intact species. Deprotonation of the terminal alkyne moieties, taking place at temperatures ranging from 300 to 350 K, triggered the formation of room-temperature stable, close-packed supramol. islands. Through DFT calculations, the stabilizing interaction was identified as a trifurcated ionic C-H···π^-δ hydrogen bonding between the π-system of the ionic alkynyl groups and methine moieties of nearby benzene rings, providing an energy gain of 0.26 eV/mol. upon network formation. Robust assemblies result from the combination of this weak directional attraction with the strong surface anchoring also provided by the alkynyl groups. The generality of this ionic hydrogen-bonding type is demonstrated by the observation of low-dimensional assemblies of 9,10-diethynyl-anthracene on the same surface, consistently explained with the same type of interaction.

Journal of Physical Chemistry C published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C26H26N4O7, COA of Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Geto, Alemnew published the artcileElectrochemical synthesis, characterisation and comparative study of new conducting polymers from amino-substituted naphthalene sulfonic acids, Formula: C10H9NO4S, the publication is Journal of Solid State Electrochemistry (2016), 20(11), 2969-2979, database is CAplus.

Conducting polymers have been synthesized electrochem. from 4-amino-3-hydroxynaphthalene-1-sulfonic acid (4A3HN1SA), 4-aminonaphthalene-1-sulfonic acid (4AN1SA) and 7-amino-4-hydroxynaphthalene-2-sulfonic acid (7A4HN2SA) on glassy carbon electrodes. The influence of the pos. potential limit on the potential cycling polymerization of 4A3HN1SA was studied, and a sufficiently high potential limit allowed better film growth. Under similar polymerization conditions, the three monomers showed different radical formation potentials and different voltammetric peak profiles. The effects of scan rate and solution pH on the electrochem. properties of the polymers were investigated, in the range between 10 and 200 mV s^-1, all the modified electrodes showing a surface-confined electrode process. In the pH range from 2.0 to 9.0, the anodic peak potentials decreased linearly with increasing pH for all the three modified electrodes. The modified electrodes were characterized by electrochem. impedance spectroscopy in pH 4.0 and 7.0 buffer solutions The results showed a more porous poly(7A4HN2SA) film, which is less affected by pH change than the other two films. SEM of the polymer films also showed significant differences in their morphologies.

Journal of Solid State Electrochemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Shim, Heesung published the artcileThe trials and tribulations of structure assisted design of KCa channel activators, Category: naphthyridine, the publication is Frontiers in Pharmacology (2019), 972, database is CAplus and MEDLINE.

Calcium-activated K+ channels constitute attractive targets for the treatment of neurol. and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homol. models of the C-terminal calmodulin-binding domain (CaM-BD) of KCa3.1 and KCa2.3 in complex with CaM using Rosetta modeling software. We here attempted to employ this atomistic level understanding of KCa activator binding to switch selectivity around and design KCa2.2 selective activators as potential anticonvulsants. In this structure-based drug design approach we used RosettaLigand docking and carefully compared the binding poses of various SKA compounds in the KCa2.2 and KCa3.1 CaM-BD/CaM interface pocket. Based on differences between residues in the KCa2.2 and KCa.3.1 models we virtually designed 168 new SKA compounds The compounds that were predicted to be both potent and KCa2.2 selective were synthesized, and their activity and selectivity tested by manual or automated electrophysiol. However, we failed to identify any KCa2.2 selective compounds Based on the full-length KCa3.1 structure it was recently demonstrated that the C-terminal crystal dimer was an artifact and suggested that the “real” binding pocket for the KCa activators is located at the S4-S5 linker. We here confirmed this structural hypothesis through mutagenesis and now offer a new, corrected binding site model for the SKA-type KCa channel activators. SKA-111 (5-methylnaphtho[1,2-d]thiazol-2-amine) is binding in the interface between the CaM N-lobe and the S4-S5 linker where it makes van der Waals contacts with S181 and L185 in the S45A helix of KCa3.1.

Frontiers in Pharmacology published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C6H4ClNO2, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Chodkiewicz, Wladyslaw published the artcileAcetylenic monoquinols; preparation of diquinols and asymmetric polyacetylenic arenes, Quality Control of 18512-55-5, the publication is Compt. rend. (1958), 2383-5, database is CAplus.

Monocondensation of anthraquinone with true acetylenic compounds, RCCH, was carried out in the presence of NaNH₂ in tetrahydrofuran or disubstituted amide solvents for 2-3 hrs. at -30° to 0° to give acetylenic monoquinols (I) as follows (R in RCCH, % yield, and m.p. of product given): H, 89, 235°; Me(CH₂)₄, 90, 130°; Ph, 83, 201°; Me₂NCH₂, 86, 215°; Ph₂C(OH), 82, 198°; Ph₂C(OH)CH₂, 77, 172°. The monoquinol Me ethers (II) were obtained almost quant. from I and Me₂SO₄ in Et₂O in the presence of powd. KOH. II with HCCH in tetrahydrofuran in the presence of KOH (30 min. to 1 hr. at 20°) gave the Me monoethers of the diquinols (III) (R, % yield, and m.p. given): Me(CH₂)₄, 98, 92°; Ph, 97, 143° and 164° (corresponding to 2 possible isomers); H, 70, 158°. Reduction of III in Et₂O-MeOH-H₂O with SnCl₂ in the presence of H₂SO₄ gave 9-ethynyl-10-(R-substituted-ethynyl)anthracene (IV) (R, % yield, and m.p. given): Ph, 83, 170° (decomposition); H, 90, 107°. IV condensed with Ph₂CO and KOH in tetrahydrofuran (5-30 min. at 20°) gave the 9-[CCC(Ph)₂OH] analog (V) as follows (R, % yield, m.p. given): Ph, 98, 178°; H, 95, 149°. The 9-(OH)9-[CCC(Ph)₂OH] 10-(:O) derivative of anthracene was reduced in Et₂O with SnCl₂ in the presence of AcCl to give 93% of the 9-(:C:C:CPh2) analog, m. 242°, the first representative of a new class of cumulenes in which the unsaturated system was conjugated with a carbonyl group.

Compt. rend. published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Quality Control of 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Chodkiewicz, Wladyslaw published the artcileDiethynylarenes, COA of Formula: C18H10, the publication is Compt. rend. (1957), 2061-2, database is CAplus.

Diethynylarenes have been prepared from 2 moles NaCCH with 1 mole quinone in liquid NH₃. In the ethynylation of p-benzoquinone, 25-30% diquinol, m. 196°, forms, along with 50% hydroquinone from the reduction of the quinone. Ethynylation of anthraquinone yields 95% diquinol, m. 206°, with N-methylpyrrolidinone or HCONH₂ as addnl. solvent at -30°; with 1 mole NaCCH/mole quinone at -50 to -60°, 40% monoquinol, m. 235°, results. Similarly, phenanthrenequinone gives 40% diquinol, m. 202°, along with other unidentified compounds Reduction of the diquinols with SnCl₂ in aqueous HOAc gives diethynylarenes. Thus, 50% diethynylbenzene, m. 96°, λ 209, 214, 258, 270, 282, and 292 mμ, was obtained by reduction at 40°. Reduction at 10-20° yields diethynylanthracene, m. 170-80° (decomposition), λ 249, 259, 349, 356, 377, and 423 mμ. These diethynylarenes give the reactions of true diacetylene compounds and can be determined with Ag salts. They condense with ketones to give glycols; thus, diethynylbenzene with anhydrous KOH in amide solvents at 0° gives with Ph₂CO 95% glycol, m. 220°; Ph₂CO and diethynylanthracene give 95% glycol, m. 256°.

Compt. rend. published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, COA of Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Busse, Madleen published the artcileSynthesis and Structure of Silver Amino-Arenesulfonates, Product Details of C10H9NO4S, the publication is European Journal of Inorganic Chemistry (2012), 2012(7), 1061-1071, database is CAplus.

Treatment of a variety of zwitterionic amino-arenesulfonic acids with Ag oxide gave seven new Ag^I amino-arenesulfonates [Ag(O₃SR)]_{âˆ?/sub> [R = o-aminobenzyl (oAB) (1), m-aminobenzyl (mAB) (2), 6-amino-3-methoxybenzyl (6A3MB) (3), o-aminonaphthyl (oAN) (4), 5-aminonaphthyl (5AN) (5), 4-amino-3-hydroxynaphthyl (4A3HN) (6) and 5-isoquinolinyl (I) (7)]. This has allowed an exploration of their coordination chem., whereby the authors examine the impact of structural diversity in the anions: the position of the amino functionality on the arene moiety, inclusion of the N within a heterocycle and an increase in ring size from Ph to naphthyl. The solid-state structures of 1, 2 and two forms of 4, one with a coordinated H2O mol., were determined by x-ray diffraction and are all polymeric. Anal. data is provided for two of the structurally known complexes: known Ag p-aminobenzenesulfonate (8) [Ag(O3SBAp)]âˆ?/sub> and Ag^I 2-pyridinesulfonate [Ag(O3SP)]âˆ?/sub> (9). The composition of all nine complexes was confirmed through NMR spectroscopy, MS-ES⁺, FTIR and elemental anal.}

European Journal of Inorganic Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Haggam, Reda Ahmed published the artcileA series of 1,3-imidazoles and triazole-3-thiones based thiophene-2-carboxamides as anticancer agents: Synthesis and anticancer activity, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is European Journal of Chemistry (2018), 9(2), 99-106, database is CAplus.

By addition of semicarbazide or phenylhydrazine hydrochloride to thienoylisothiocyanate resulted in building of thiosemicarbazide derivative , triazole derivative and thiophene-2-carboxamide, resp. Basic cyclization of thiosemicarbazide derivative led to formation of oxadiazine. Synthesis of thiadiazine derivative was achieved via reaction of thiophene-2-carboxamide and maleic anhydride in tri-Et amine. Heating of thiophene-2-carboxamide with Et chloroacetate or sodium ethoxide produced thiadiazine derivative and triazolethione, resp. Thiosemicarbazide derivative was synthesized by addition of nicotinic hydrazide to thienoylisothiocyanate. Refluxing of Thiosemicarbazide derivative with lead acetate afforded triazole. Moreover, acid and base mediated cyclizations of thiosemicarbazide derivative gave thiadiazole and 1,2,4-triazolethione throughout thiophene intermediate, resp. Addition of Et 2-aminothiophene-3-carboxylate to thienoylisothiocyanate formed thiourea which was refluxed with ethoxide giving thiophene-3-carboxylic acid. Lastly, nucleophilic addition of amino phenol or ethylene diamine to thienoylisothiocyanate yielded oxazine structure and imidazole derivative, resp. The yields of the synthesized compounds were 61-95%. The detailed synthesis and spectroscopic data of the new compounds were reported.

European Journal of Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Recommanded Product: 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gado, Mohamed published the artcileThe role of graphene oxide anchored 1-amino-2-naphthol-4-sulphonic acid on the adsorption of uranyl ions from aqueous solution: kinetic and thermodynamic features, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is International Journal of Environmental Analytical Chemistry (2019), 99(10), 996-1015, database is CAplus.

Graphene oxide-1-amino-2-naphthol-4-sulfonic acid (GOANS) adsorbent synthesized successfully from a natural source (cattle bones) for the U(VI) ions removal from liquid waste solutions The synthesized adsorbent characterized via Fourier transform IR (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET) surface area anal., energy-dispersive x-ray spectroscopy (EDX) pattern, and SEM. Various exptl. parameters (time, adsorbent weight, initial uranium concentration and temperature) investigated and the results reveal that a higher uptake capacity of 311.5 mg/g achieved at pH 4 within 60 min. The obtained findings fitted well with thermodn., isothermal (Langmuir and Freundlich model) and pseudo second order kinetics. The neg. sign of (ΔG°)specified the spontaneity of adsorption process in the thermodn. study, (ΔH°) and pos. sign (ΔS°) indicate high randomness after adsorption.

International Journal of Environmental Analytical Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gado, Mohamed A. published the artcileThorium ions adsorption from aqueous solution by amino naphthol sulphonate coupled chitosan, Quality Control of 116-63-2, the publication is International Journal of Environmental Analytical Chemistry (2021), 101(10), 1419-1436, database is CAplus.

A designed new adsorbent by coupling chitosan and 1-Amino-2-naphthol-4-sulfonic acid to get an excellent synergistic effect of 1-Amino-2-naphthol-4-sulfonic coupled chitosan (ANSC) which used for the removal of tetravalent thorium ions. The modified chitosan adsorbent was identified by BET isotherm studies, elemental anal., SEM, EDX and FT-IR, techniques. The FT-IR confirmed the structure of the modified chitosan. Langmuir isotherm model described the adsorption results with the 252.57 mg/g maximum adsorption capacity. It should be perceived that the thorium ions adsorption matched more careful with the kinetics pseudo-second-order. It was found that the adsorption of Th(IV) is strongly dependent on pH and time.

International Journal of Environmental Analytical Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Lee, Taegweon published the artcileStereoselective Hydroboration of Diynes and Triyne to Give Products Containing Multiple Vinylene Bridges: A Versatile Application to Fluorescent Dyes and Light-Emitting Copolymers, Safety of 9,10-Diethynylanthracene, the publication is Organometallics (2004), 23(20), 4569-4575, database is CAplus.

The Rh(I)-catalyzed hydroboration of a variety of aromatic diynes and a triyne afforded bis(boryl)- and tris(boryl)vinyl products. The hydroboration products underwent Suzuki cross-coupling reactions with a variety of substrates containing chromophore units to give fluorescent dye-substituted products. The hydroboration product also reacted with dibromoarenes to afford an oligomer with a vinylene unit along the oligomer backbone.

Organometallics published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Safety of 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem