Tag: M.W:200-300

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Direct synthesis of ester-containing indium homoenolate and its application in palladium-catalyzed cross-coupling with aryl halide, the main research direction is indium ester homoenolate preparation coupling aryl halide.COA of Formula: C5H3IO2.

An efficient method for the synthesis of ester-containing indium homoenolate via a direct insertion of indium into β-halo ester in the presence of CuI/LiCl is described. The synthetic utility of the indium homoenolate was demonstrated by palladium-catalyzed cross-coupling with aryl halides in DMA with wide functional group compatibility.

As far as I know, this compound(2689-65-8)COA of Formula: C5H3IO2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specific inhibitors, published in 2021-12-05, which mentions a compound: 65438-97-3, Name is 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, Molecular C7H8BrNO, Category: naphthyridine.

Transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer and neurodegenerative diseases. However, the lack of specific inhibitors impedes the development of TRPM2 targeted therapeutic agents. To develop a selective TRPM2 inhibitor, three-dimensional similarity-based screening strategy was employed using the energy-minimized conformation of non-selective TRPM2 inhibitor 2-APB as the query structure, which resulted in the discovery of a novel tricyclic TRPM2 inhibitor I with benzo[d]imidazo[1,2-a]imidazole skeleton. A series of I derivatives were subsequently synthesized and evaluated using calcium imaging and electrophysiol. approaches. Among them, preferred compounds II and III inhibited the TRPM2 channel with micromolar half-maximal inhibitory concentration values and exhibited TRPM2 selectivity over the TRPM8 channel, TRPV1 channel, InsP3 receptor and Orai channel. The anal. of structure-activity relationship provides valuable insights for further development of selective TRPM2 inhibitors. Neuroprotection assay showed that II and III could effectively reduce the mortality of SH-SY5Y cells induced by H2O2. These findings enrich the structure types of existing TRPM2 inhibitors and might provide a new tool for the study of TRPM2 function in Reactive oxygen species (ROS) -related diseases.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone( cas:65438-97-3 ) is researched.Product Details of 65438-97-3.Howes, Peter D.; Cleasby, Anne; Evans, Derek N.; Feilden, Helen; Smith, Paul W.; Sollis, Steven L.; Taylor, Neil; Wonacott, Alan J. published the article 《4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase》 about this compound( cas:65438-97-3 ) in European Journal of Medicinal Chemistry. Keywords: acetylaminoimidazolylbenzoic acid preparation influenza sialidase inhibitor; imidazolylbenzoic acid preparation influenza sialidase inhibitor; benzoic acid imidazolyl preparation influenza sialidase inhibitor; virucide anti viral agent acetylaminoimidazolylbenzoic acid. Let’s learn more about this compound (cas:65438-97-3).

Two methods for the synthesis of 4-acetylaminobenzoic acids substituted at the 3-position with imidazoles are described. Thus, 4-acetylamino-3-aminobenzoic acid tert-Bu ester was N-alkylated with RCH2COBr (R = Ph, Et, benzofuran-3-yl, etc.) followed by cyclization with cyanamide and hydrolysis to give imidazolylbenzoic acids I (R1 = Ph, furyl, Et, etc.; R2 = NH2). Imidazolylbenzoic acids I (R1 = H; R2 = NH2, H, Et) were prepared by addition of the appropriate imidazole to 3-fluoro-4-nitrobenzoic acid tert-Bu ester followed by reduction of the nitro group, acetylation, and hydrolysis. Many of the compounds are inhibitors of influenza virus sialidases with levels of activity similar to the recently described 4-acetylamino-3-guanidino-benzoic acid (BANA 113).

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

COA of Formula: C5H3IO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Mechanism and kinetics of furfural oxidation by hydrogen peroxide. Author is Badovskaya, L. A.; Kul’nevich, V. G.; Muzychenko, G. F.; Kaklyugina, T. Ya..

The 1st-order rate constants and activation parameters for oxidation of furfural by H2O2 and the effect of 5-substituents on the rate constant indicated a heterolytic mechanism with loss of rotational and translational degrees of freedom in the transition state.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Organicheskoi Khimii called Kinetics and mechanism of the acetalation of 5-substituted furfural, Author is Kul’nevich, V. G.; Zelikman, Z. I.; Pustovarov, V. S., which mentions a compound: 2689-65-8, SMILESS is IC1=CC=C(O1)C=O, Molecular C5H3IO2, Application In Synthesis of 5-Iodo-2-furaldehyde.

The rate of formation of acetals from 5-substituted furfurals (I, R = Er2N, Me2N, Me, H, Cl, Br, I, NO2) and pentaerythritol dichlorohydrin, MeC(CH2OH)3, EtC(CH2OH)3, or BuOH in C6H6 in the presence of KU-2 cation-exchange resin (H form) increased in the stated order of R and alcs. The rate constants correlated with the Brown σn+ constants of R.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

D’Auria, Maurizio; Vantaggi, Anna published the article 《1H-Indenylfuran and -thiophene derivatives: a new class of singlet-oxygen sensitizers》. Keywords: singlet oxygen sensitizer indenylfuran indenylthiophene; fluorescence indenylfuran indenylthiophene; UV spectra indenylfuran indenylthiophene; triplet energy indenylthiophene.They researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).Quality Control of 5-Iodo-2-furaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2689-65-8) here.

Photophys. and photochem. properties of title compounds I (X = O, S; R = H, Me) and II (R = H, inden-2-yl) were studied. All the compounds absorbed UV light at 350-380 nm. The fluorescence spectra of I and II showed bands at 410-470 nm and quantum yields in the range 0.25-0.88. Attempts to calculate the triplet energy failed except for I (X = S, R = Me) and II (R = H), which showed ET = 43-44 kcal mol-1. These compounds are a new class of singlet-oxygen sensitizers. The sensitized reaction of 2,5-dimethylfuran with singlet oxygen was followed. I (X = O, R = H) and II (R = inden-2-yl) are more reactive than α-terthiophene (III), while the other compounds show the same reactivity as III. This behavior can be explained by different intersystem crossing quantum yields. Diazabicyclo[2.2.2]octane is a quencher of singlet oxygen in this reaction. Superoxide ion formation is excluded by photooxidation of α,α’-dimethylstilbene.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Recommanded Product: 5-Iodo-2-furaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Electrochemically Promoted Nickel-Catalyzed Carbon-Sulfur Bond Formation. Author is Wang, Yang; Deng, Lingling; Wang, Xiaochen; Wu, Zhengguang; Wang, Yi; Pan, Yi.

This work describes a nickel-catalyzed Ullmann-type thiolation of aryl iodides under mild electrochem. conditions. The simple undivided cell with graphite felt/nickel foam electrode setups offers excellent substrate tolerance, affording aryl and alkyl sulfides in good chem. yields. Furthermore, the mechanism for this electrochem. cross-coupling reaction has been investigated by cyclic voltammetry.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ) is researched.Recommanded Product: 5-Iodo-2-furaldehyde.Povazanec, F.; Piklerova, A.; Kovac, J.; Kovac, S. published the article 《Furan derivatives. XLVI. Infrared spectra of substituted 2-furyl cyanides》 about this compound( cas:2689-65-8 ) in Chemicke Zvesti. Keywords: IR furyl cyanide; substituent effect IR furonitrile; solvent effect IR furonitrile. Let’s learn more about this compound (cas:2689-65-8).

The spectral data of the cyanides I (R = H, halo, Me, NO2, AcO) in CHCl3 and CCl4 were given and the influence of substituents and solvents on the wave numbers and integrated absorption intensities of the ν(CN) bands discussed. Wave numbers of the ν(CN) bands increased with increasing electron-acceptor ability of the substituents; the wave numbers were higher than those of the corresponding substituted Ph cyanides. Integrated absorption intensities of the ν(CN) bands decreased with increasing electron-acceptor ability of the substituents and were more significantly influenced by the nature of the substituents and the polarity of the solvents than the wave numbers of these bands.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Name: 5-Iodo-2-furaldehyde. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about 3-(5-X-2-Furyl)-2-cyanoacrylonitriles on reaction with 2-cyanomethylbenzothiazole. Author is Kada, Rudolf; Ilavasky, Dusan; Goljer, Igor; Gaher, Peter.

2-Cyanomethylbenzothiazole reacts with 3-(5-substituted 2-furyl)-, 3-(2-thienyl)- or 3-(2-pyrrolyl)-2-cyanoacrylonitrile in THF under catalysis of triethylamine to give 1-(2-benzothiazolyl)-1-acyano-2-heteroarylethylenes e.g. I (R = H, X = O, S, NH; R = Br, Me, NO2, X = O) as a result of replacement of malonodinitrile by 2-cyanomethylbenzothiazole.

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1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ) is researched.SDS of cas: 2689-65-8.Mocelo, R.; Pustovarov, V. published the article 《Study of the nucleophilic substitution of halogens in furan compounds. (I). Furfurals》 about this compound( cas:2689-65-8 ) in Revista sobre los Derivados de la Cana de Azucar. Keywords: halogenation furfural; halofurfural halogen exchange. Let’s learn more about this compound (cas:2689-65-8).

5-Bromofurfural (I, R = Br) was prepared by treating I (R = H) in dichloroethane with Br in the presence of hydroquinone. Reaction of I (R = Br) with LiCl in DMF gave 74% I (R = Cl) and with KI-HOAc gave 80% I (R = I). I (R = I) was similarly obtained in 44% yield from I (R = Cl). I (R = Cl) could also be converted to I (R = Br) with KBr-HOAc.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem