Tag: M.W:200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Revista CENIC, Ciencias Fisicas called Chemical shifts and JC13-H coupling constants in 5-substituted furfurals, Author is Rodriguez, M.; Gra Rios, Rafael, which mentions a compound: 2689-65-8, SMILESS is IC1=CC=C(O1)C=O, Molecular C5H3IO2, Name: 5-Iodo-2-furaldehyde.

The coupling constants between 13C and H were obtained from the PMR spectra of 5 substituted furfurals in 3M solutions in Me2SO. The charge ds. were calculated by using the Pariser Parr-Pople method. Good correlations were found for the chem. shifts for the H atom except for the 3 position. Therefore in positions 4 and α, the chem. shifts depend mainly of the π-electron d., whereas for the 3 position, the mesomeric effect of the substituent may be neglected. For the coupling constants there is a linear relation between JC13-Hα, JC13-H3 and the McDaniel and Brown (1958) constants σp and σm resp. For JC13-H4 vs. σp, the correlation is poor. The linear correlation between JC13-H3 and the chem. shifts for the H in position 3 implies that the chem. shifts in the 3 position are determined by electronic factors, mainly by variations in the σ-electron d.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2689-65-8, is researched, Molecular C5H3IO2, about Ligand-Promoted meta-C-H Functionalization of Benzylamines, the main research direction is ligand promoted meta CH functionalization benzylamine; amination; benzylamines; chlorination; meta-C−H arylation; pyridone ligand.Synthetic Route of C5H3IO2.

Meta-C-H functionalization of benzylamines has been developed using a PdII/transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2689-65-8, is researched, Molecular C5H3IO2, about Novel Allosteric Ligands of γ-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries, the main research direction is nipecotic acid pseudostatic hydrazone library preparation GAT1 allosteric ligand.SDS of cas: 2689-65-8.

This study describes the screening of dynamic combinatorial libraries based on nipecotic acid as core structure with substituents attached to the 5- instead of the common 1-position for the search of novel inhibitors of the GABA transporter GAT1. The generated pseudostatic hydrazone libraries included a total of nearly 900 compounds and were screened for their binding affinities toward GAT1 in competitive mass spectrometry (MS) based Binding Assays. Characterization of the hydrazones with the highest affinities (with cis-configured compound I bearing a 5-(1-naphthyl)furan-2-yl residue and a four atom spacer being the most potent) in binding and uptake experiments revealed an allosteric interaction at GAT1, which was not reported for any other nipecotic acid derivative up to now. Therefore, the herein introduced 5-substituted nipecotic acid derivatives could serve as valuable tools for investigations of allosterically modulated GABA transport mediated by GAT1 and furthermore as starting point for a new class of GAT1 inhibitors.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Direct synthesis of ester-containing indium homoenolate and its application in palladium-catalyzed cross-coupling with aryl halide, published in 2011, which mentions a compound: 2689-65-8, Name is 5-Iodo-2-furaldehyde, Molecular C5H3IO2, Product Details of 2689-65-8.

An efficient method for the synthesis of ester-containing indium homoenolate via a direct insertion of indium into β-halo ester in the presence of CuI/LiCl is described. The synthetic utility of the indium homoenolate was demonstrated by palladium-catalyzed cross-coupling with aryl halides in DMA with wide functional group compatibility.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Iodo-2-furaldehyde(SMILESS: IC1=CC=C(O1)C=O,cas:2689-65-8) is researched.Electric Literature of C10H11NO3. The article 《Knoevenagel condensation of some 5-substituted furan-2-carboxaldehyde with creatinine and their antimicrobial screening》 in relation to this compound, is published in International Journal of ChemTech Research. Let’s take a look at the latest research on this compound (cas:2689-65-8).

A series of heterocyclic compounds of 5-(5-R-furfurylidene)-creatinine were prepared and screened for their antimicrobial activity, these compounds were identified by their m.ps., IR, Ultraviolate and NMR spectra.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation.Recommanded Product: 5-Iodo-2-furaldehyde.

The enzymic β-C-H hydroxylation of the feedstock chem. isobutyric acid has enabled the asym. synthesis of a wide variety of polyketides. The analogous transition metal-catalyzed enantioselective β-C-H functionalization of isobutyric acid-derived substrates should provide a versatile method for constructing useful building blocks with enantioenriched α-chiral centers from this abundant C-4 skeleton. However, the desymmetrization of ubiquitous iso-Pr moieties by organometallic catalysts has remained an unanswered challenge. Herein, the authors report the design of chiral mono-protected aminomethyl oxazoline ligands that enable desymmetrization of iso-Pr groups via palladium insertion into the C(sp3)-H bonds of one of the prochiral Me groups. We detail the enantioselective β-arylation, -alkenylation, and -alkynylation of isobutyric acid/2-aminoisobutyric acid derivatives, which may serve as a platform for the construction of α-chiral centers.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Direct Synthesis of Water-Tolerant Alkyl Indium Reagents and Their Application in Palladium-Catalyzed Couplings with Aryl Halides, Author is Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Yang, Yong-Sheng; Lai, Yin-Chang; Wong, Colin Hong An; Cheong, Hao-Lun; Loh, Teck-Peng, which mentions a compound: 2689-65-8, SMILESS is IC1=CC=C(O1)C=O, Molecular C5H3IO2, COA of Formula: C5H3IO2.

A mild, efficient and straightforward method for the synthesis of water-tolerant alkyl indium reagent through CuCl-mediated direct insertion of indium into alkyl halide in THF at room temperature is described.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Thiocyanopyrrole, thiopyrroles and pyrrole disulfides》. Authors are Pratesi, P..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Product Details of 2689-65-8. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

Thiocyanopyrroles have been prepared by addition of Br2 to pyrrole and NH4SCN in glacial AcOH, theoretical quantities being used according to the scheme RH + 2NH4SCN + Br2 → RSCN + 2NH4Br + HSCN. With ordinary pyrrole, the reaction mix is cooled with ice and salt. The yields are 90-5%. 2,4-Dimethyl-3-carbethoxy-5-thiocyanopyrrole (I), m. 169.5°. The 5-carbethoxy-3-thiocyano derivative (II), m. 198-9°. A dithiocyanopyrrole, C4H3N(SCN)2, m. 114°, was the only product obtained in an attempt to produce the tetrathiocyanate. Thiocyanopyrroles are very stable compounds, indifferent toward alkalies. They crystallize very readily, usually in needle form, and are readily purified and recrystallized from H2O or EtOH. With Zn and AcOH the corresponding thiopyrrole is formed. Thus, 2,4-dimethyl-5-carbethoxy-3-thiopyrrole (III), m. 140°, is formed by the reduction of II; yield, 50%. These compounds resemble the thiophenols, being soluble in alkali and insoluble in alk. bicarbonates. They react readily with Hg salts, giving compounds of the types: RSHgX, and (RS)2Hg [X = halogen]. The thiopyrroles oxidize readily in air, forming the disulfides. Oxidation of III by boiling in the presence of bone black gave bis[2,4-dimethyl-5-carbethoxy-3-pyrryl disulfide. On cooling the disulfide seps. quantitatively, as a white powder, m. 234°, insoluble in alkali, slightly soluble in EtOH. IV was also obtained directly from the NCS derivative by reduction with Na and EtOH.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.D’Auria, Maurizio researched the compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ).Category: naphthyridine.They published the article 《Photochemical reactivity of halofuran and halothiophene derivatives with benzimidazole》 about this compound( cas:2689-65-8 ) in Heterocycles. Keywords: iodofuran benzimidazole photochem coupling; iodothiophene benzimidazole photochem coupling; benzimidazolylthiophene; benzimidazolylfuran; thiophene benzimidazolyl; furan benzimidazolyl. We’ll tell you more about this compound (cas:2689-65-8).

A photochem. approach to the synthesis of 5-(4-benzimidazolyl)-2-thiophenes, e.g., I (X = S, R = H, Me) and 5-(4-benzimidazolyl)-2-furan I (X = O, R = H) by the irradiation of benzimidazole with iodothiophenes II (X = S, R = H, Me) and iodofuran II (X = O, R = H) in MeCN is described.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Infrared spectroscopic study of the condensation reaction of halofurfural with ketones》. Authors are Usmanov, Z.; Tadzhieva, M. A..The article about the compound:5-Iodo-2-furaldehydecas:2689-65-8,SMILESS:IC1=CC=C(O1)C=O).Application of 2689-65-8. Through the article, more information about this compound (cas:2689-65-8) is conveyed.

The reactions of furfuryl iodide (I) and bromide (II) with ketones were investigated. NaOH (3-5 ml., 5%), 0.05 mole halofurfural, and 0.8-3 ml. ketone were added to 20 ml. solvent. The reaction lasted 1-2 hrs. The product was precipitated with 30-50 ml. H2O and dried. The light-yellow oily products were investigated in C2H4Cl2 solutions, the crystalline products in pressed KBr disks. The compositions of the condensation products of I with methyl nonyl ketone, methyl naphthyl ketone, and acetophenone were C16H23O2I, C17H11O2I, and C13H9O2I, resp. The condensations of II with methyl alkyl ketones, where the alkyl group was Et, Pr, Bu, amyl, hexyl, isopropyl, and isobutyl, and with acetophenone and acetylacetone, led to C9H9O2Br, C10H11O2Br, C11H13O2Br, C12H15O2Br, C13H17O2Br, C10H11O2Br, C11H13O2Br, C13H9O2Br, and C10H9O3Br, resp. The ir spectra indicate the functional groups present in the various products.

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1,8-Naphthyridine – Wikipedia,
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