Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C12H8ClFN2O3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 100361-18-0

A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested Gram-positive strains including MRSA and MRSE (MIC: <0.008-8 mug/mL), although they are generally less active than the references against the Gram-negative strains. In particular, compound 11l (MIC: <0.008-4 mug/mL) was found to be 8-2048 and 2-128 times more potent than levofloxacin (LVFX) and GMFX against the Gram-positive strains, respectively. Moreover, against MRSA clinical isolates, 11l (MIC90: 1 mug/mL) is 8-fold more active than GMFX, and 2-fold more active than GMFX and moxifloxacin against MRSE clinical isolates (MIC90: 4 mug/mL). Crown Copyright If you are interested in 100361-18-0, you can contact me at any time and look forward to more communication. Computed Properties of C12H8ClFN2O3

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1,718-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N712 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C8H5BrN2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 54569-28-7

MERCK PATENT GMBH; SHERER, Brian A.; BRUGGER, Nadia

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

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1,604-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N598 – PubChem

Reference of 100361-18-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.100361-18-0, Name is 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, molecular formula is C12H8ClFN2O3. In a Patent£¬once mentioned of 100361-18-0

ACTELION PHARMACEUTICALS LTD; HUBSCHWERLEN, Christian; RUEEDI, Georg; SURIVET, Jean-Philippe; ZUMBRUNN ACKLIN, Cornelia

The invention relates to antibacterial compounds of formula I (Fornula I) (I) wherein R la represents H or carboxy and R1b represents H, or R1a and R1b represent together either the group *-C(0)-NH-S-# or the group *-C(OH)=N-S-# wherein “*” represents the point of attachment of R1a and ??#?? represents the point of attachment of R1b; R2 represents H, (C1-C3 )alkyl, hydroxy-(C1 C3 )alkyl, benzyl or (C3-C5)cycloalkyl; R3 represents H or halogen; U represents N or CR4; wherein R4 is H or (C1-C3)alkoxy; A represents CH, B represents NH and m represents 1 or 2 and n represents 1 or 2; or A represents N, B is absent, m represents 2 and n represents 2; Y represents CH or N; and Q represents O or S; and salts of such compounds.

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1,679-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N673 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 3-Bromo-1,5-naphthyridine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 17965-71-8, name is 3-Bromo-1,5-naphthyridine. In an article£¬Which mentioned a new discovery about 17965-71-8

Crystallography has guided the hybridization of two series of Trypanosoma brucei N-myristoyltransferase (NMT) inhibitors, leading to a novel highly selective series. The effect of combining the selectivity enhancing elements from two pharmacophores is shown to be additive and has led to compounds that have greater than 1000-fold selectivity for TbNMT vs HsNMT. Further optimization of the hybrid series has identified compounds with significant trypanocidal activity capable of crossing the blood-brain barrier. By using CF-1 mdr1a deficient mice, we were able to demonstrate full cures in vivo in a mouse model of stage 2 African sleeping sickness. This and previous work provides very strong validation for NMT as a drug target for human African trypanosomiasis in both the peripheral and central nervous system stages of disease.

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1,594-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N588 – PubChem

Electric Literature of 100361-18-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.100361-18-0, Name is 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, molecular formula is C12H8ClFN2O3. In a Patent£¬once mentioned of 100361-18-0

Bayer Aktiengesellschaft

New 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxy lic acids of the formula (I) STR1 in which X represents halogen or nitro and A represents STR2 wherein R1, R2, R3 and R4 are defined hereinbelow are disclosed as well as their usefulness as antibacterial agents.

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1,697-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N691 – PubChem

72754-05-3, Name is 6-Bromo-1,8-naphthyridin-2-ol, belongs to naphthyridine compound, is a common compound. Recommanded Product: 72754-05-3In an article, once mentioned the new application about 72754-05-3.

NATCO PHARMA LIMITED; KOMPELLA, Amala; GAMPA, Venugopala Krishna; GANGANAMONI, Srinivasulu; SIRIGIREDDY, Balakrishna Reddy; ADIBHATLA, Kali Satya Bhujanga Rao; NANNAPANENI, Venkaiah Chowdary

The present invention relates to novel antiproliferative1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance.

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1,643-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N637 – PubChem

Related Products of 72754-05-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.72754-05-3, Name is 6-Bromo-1,8-naphthyridin-2-ol, molecular formula is C8H5BrN2O. In a Patent£¬once mentioned of 72754-05-3

OTSUKA PHARMACEUTICAL CO., LTD.; ABUDUSAIMI, Mamuti; YE, Fangguo; SUN, Jiangqin; MIYAMOTO, Hisashi; CHENG, Jay-Fei; OKA, Daisuke

The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-l,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea

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1,640-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N634 – PubChem

Reference of 64874-38-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 64874-38-0, molcular formula is C8H6BrN3, introducing its new discovery.

GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, Dave Norman; SHEARER, Barry George; YOUNGMAN, Mark Andrew

A compound of formula (I) wherein R1, R2, R3, R4, X, Y, and A are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 64874-38-0 is helpful to your research. Reference of 64874-38-0

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1,636-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N630 – PubChem

Application of 17965-71-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.17965-71-8, Name is 3-Bromo-1,5-naphthyridine, molecular formula is C8H5BrN2. In a Patent£¬once mentioned of 17965-71-8

Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; Liang Jinsheng; Zou Zhifu; Tu Linjin; Shan Yuefeng; Lei Douxing; S ¡¤geerdeman; Zhang Yingjun

The invention relates to a 4 – methyl dihydropyrimidine compounds and their use as medicaments, in particular for the treatment and prevention of hepatitis b in the application of the medicament. In particular, the invention relates to the general formula (I) or (Ia) compound of formula or its enantiomer, non-enantiomeric isomer, tautomer, hydrate, solvate or pharmaceutically acceptable salt, wherein the variables are defined in the specification. The invention also relates to the general formula (I) or (Ia) compound of formula or its enantiomer, non-enantiomeric isomer, tautomer, hydrate, solvate or pharmaceutically acceptable salt as the pharmaceutical use, especially for the treatment and prevention of hepatitis b use of the medicament. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 17965-71-8

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1,584-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N578 – PubChem

Application of 100361-18-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 100361-18-0, Name is 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid,introducing its new discovery.

JANSSEN PHARMACEUTICA, N.V.

The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.

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1,659-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N653 – PubChem