Tag: M.W:300-400

Chemical Research Letters, May 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. , Formula: https://www.ambeed.com/products/298-96-4.html, 298-96-4, Name is Tetrazolium Red, molecular formula is C19H15ClN4, belongs to naphthyridine compound. In a document, author is Sonyanaik, B., introduce the new discover.

An efficient synthesis of 6-(2-chloro-4-fluorophenyl)-9-phenylimidazo[1,2-a][1,8]naphthyridine derivatives by the reaction of phenacyl bromide with substituted heterocyclic amines in the presence of DABCO catalyst is described. Solid state conditions of the process accelerate accumulation of the targeted products with high yields and exclude formation of side-products. Antibacterial and fungal activities tests of all newly synthesized products demonstrate their pronounced potency, which is the highest for compounds 5c-5e. Molecular docking studies support well with the antimicrobial activity data accumulated for the products.

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, their interactions with reaction intermediates and transition states. I hope my blog about 298-96-4 is helpful to your research. Formula: https://www.ambeed.com/products/298-96-4.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical Research Letters, May 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials. In an article, author is Defaux, Julien, once mentioned the application of 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene. Now introduce a scientific discovery about this category, Recommanded Product: 5089-22-5.

As part of our research projects to identify new chemical entities of biological interest, we developed a synthetic approach and the biological evaluation of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of Aurora kinase inhibitors for the treatment of malignant diseases based on pathological cell proliferation. 1,5-Naphthyridine derivatives showed excellent inhibitory activities toward Aurora kinases A and B, and the most active compound, 1-cyclopropyl-3-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]urea (49), displayed IC50 values of 13 and 107nM against Aurora kinases A and B, respectively. In addition, the selectivity toward a panel of seven cancer-related protein kinases was highlighted. In vitro ADME properties were also determined in order to rationalize the difficulties in correlating antiproliferative activity with Aurora kinase inhibition. Finally, the good safety profile of these compounds imparts promising potential for their further development as anticancer agents.

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1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical Research Letters, May 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials. In an article, author is Patil, Sandeep R., once mentioned the application of 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate. Now introduce a scientific discovery about this category, Quality Control of tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate.

The blue light-emitting pyrazolo[3,4-h][1,6]naphthyridines has been synthesized by Friedlander condensation of 4-amino-3-(4-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (o-aminoaldehyde) 1 with different cyclic ketones and 1,3-diketones. The synthesized angular polycyclic naphthyridine derivatives were studied for Semi-empirical, thermal, UV-vis and fluorescence spectroscopic properties on binding with bovin serum albumin (BSA). These fluorescence properties together with the neutral, hydrophobic nature of these compounds make these fluorophores good fluorescence probe for studying the micropolarity of proteins like BSA and in general the ligand-protein interactions. All of them displays bright absorption at 394 nm & emission in visible region (491 nm). Quantum yields of all synthesized compounds were calculated.

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 286961-14-6. Quality Control of tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

New Advances in Chemical Research in 2021. In an article, author is Stockmann, Vegar, once mentioned the application of 16415-12-6, Name is Hexadecyltrimethoxysilane, molecular formula is C19H42O3Si, molecular weight is 346.62, category is naphthyridine. Now introduce a scientific discovery about this category, Name: Hexadecyltrimethoxysilane.

The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlander condensation to give different 1,7-naphthyridines has been demonstrated. 2,4-Disubstituted 1,7-naphthyridine 8 was prepared from 3-amino-4-acetylpyridine (6) and ketone 4 (82%). The Friedlander self-condensation of pyridyl substrate 6 is reported, as well. The dimer product, 2-(3-aminopyridin-4-yl)-4-methyl- 1,7-naphthyridine (7), was obtained in 97% yield. 2-Aryl-and 2,3-diaryl-1,7-naphthyridines (1618) were prepared from 3-aminoisonicotinaldehyde (13) and arylketones 4, 14, and 15 (28-71%). The key substrates 6 and 13 are readily available via the improved pyridine nitration method.

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, their interactions with reaction intermediates and transition states. I hope my blog about 16415-12-6 is helpful to your research. Name: Hexadecyltrimethoxysilane.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

New Advances in Chemical Research, April 2021. Electric Literature of 179324-87-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 179324-87-9, Name is (R)-BoroLeu-(+)-Pinanediol trifluoroacetate, SMILES is CC1(C)[C@@]([H])(C2)C[C@]3([H])[C@](OB([C@H](CC(C)C)N)O3)(C)[C@]12[H].O=C(O)C(F)(F)F, belongs to naphthyridine compound. In a article, author is Manera, C, introduce new discover of the category.

A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A(1)AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A(2A)AR. (c) 2005 Elsevier Ltd. All rights reserved.

Electric Literature of 179324-87-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 179324-87-9.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical Research Letters, April 2021. Reference of 179324-87-9, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 179324-87-9, Name is (R)-BoroLeu-(+)-Pinanediol trifluoroacetate, SMILES is CC1(C)[C@@]([H])(C2)C[C@]3([H])[C@](OB([C@H](CC(C)C)N)O3)(C)[C@]12[H].O=C(O)C(F)(F)F, belongs to naphthyridine compound. In a article, author is Chahal, Mandeep K., introduce new discover of the category.

Two new receptors viz. 2-bromoacetamido-5,7-dimethyl-1,8-naphthyridine (1a) and 2-chloroacetamido-5,7-dimethyl-1,8-naphthyridine (1b) containing 1,8-naphthyridine as fluorophore unit have been designed and synthesised. These receptors exhibited very high selectivity for F- ions among the various anions tested such as H2PO4-, OAc-, Cl-, Br-, I-, HSO4-, PF6-, ClO4-, BF4- and NO3- owing to anion-induced deprotonation of the amide NH by F- ions. Among the various cations tested (Na+, Ag+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ and Mn3+), 1a exhibited selective detection of Hg2+ ions by binding with N1 and N8 atoms of the naphthyridine moiety. Receptor 1a has been explored as a dual-ion detector for F- and Hg2+ ions in two contrasting modes (fluorescence ‘turn-on’ and ‘turn-off’) which is supported by spectroscopic and lifetime measurements. 1a exhibited lower detection limits for F- (0.4 ppm) and Hg2+ (2.4 ppm) ions. These receptors were recovered from anionic species of 1a formed after addition of F- ions by treating with protic solvents such as CH3OH. The mode of binding was also confirmed by spectroscopic and DFT studies. The chemical inputs of F- and Hg2+ ions generate an output which satisfies the condition of two-input INHIBIT logic operators.

Reference of 179324-87-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 179324-87-9 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

New Advances in Chemical Research, April 2021. Related Products of 286961-14-6, The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate, SMILES is O=C(N1CCC(B2OC(C)(C)C(C)(C)O2)=CC1)OC(C)(C)C, belongs to naphthyridine compound. In a article, author is Showalter, H. D. Hollis, introduce new discover of the category.

Short pathways are described for the synthesis of a representative example of each of the 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-one ring systems from simple pyridine precursors. An attempted synthesis of the related 4,6-dihydro-1,6-naphthyridin-5(1H)-one ring system from a common intermediate was unsuccessful.

Related Products of 286961-14-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 286961-14-6 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

New Advances in Chemical Research in 2021. In an article, author is Mogilaiah, K., once mentioned the application of 16415-12-6, Name is Hexadecyltrimethoxysilane, molecular formula is C19H42O3Si, molecular weight is 346.62, category is naphthyridine. Now introduce a scientific discovery about this category, Product Details of 16415-12-6.

A high yielding and rapid method of Claisen-Schmidt condensation of 2-(4-acetylphenylamino)-3-(4-fluorophenyl)-1,8-naphthyridine 3 with various aromatic aldehydes in the presence of solid KOH in combination with microwave irradiation and also with a pestle and mortar under solvent-free conditions affords 2(4-cinnamoylphenylamino)-3-(4-fluorophenyl)-1,8-naphthyridines (chalkones or alpha, beta-unsaturated ketones) 4 is described.

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 16415-12-6. Product Details of 16415-12-6.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemical Research Letters, May 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. , Computed Properties of https://www.ambeed.com/products/286961-14-6.html, 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C16H28BNO4, belongs to naphthyridine compound. In a document, author is Li, Zhan-Xian, introduce the new discover.

Two new phenolic Schiff bases 1 and 2 based on 1,8-naphthyridine were synthesized. The phenomena of ethanolic solutions of compounds 1 and 2 upon adding sodium hydroxide ethanolic solutions, and of the above solutions in air for some time have been studied by UV-vis absorption spectra. Especially, the exact structures of 1b and 2b have also been studied. (c) 2006 Elsevier Ltd. All rights reserved.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. I hope my blog about 286961-14-6 is helpful to your research. Computed Properties of https://www.ambeed.com/products/286961-14-6.html.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

New research progress on 286961-14-6 in 2021. 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C16H28BNO4, SDS of cas: 286961-14-6, SMILES is O=C(N1CCC(B2OC(C)(C)C(C)(C)O2)=CC1)OC(C)(C)C belongs to naphthyridine compound, is a common compound. In a patnet, author is Sirakanyan, Samvel N., once mentioned the new application about 286961-14-6.

Background and Objective: Continuing our studies in the field of a new rearrangement in the 2,7-naphthyridine series, the synthesis and rearrangement of mono-2 and di-amino derivatives 3 of 2,7-naphthyridine was carried out. Taking into account the wide range of pharmacological activities of pyrazole derivatives the synthesis of some 3-amino-1-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-naphthyridines 8 and of pyrazolo[3,4-c]-2,7-naphthyridine 12 was described. Methods: Compounds 2 were reacted with amines furnishing the relevant rearrangement products 4. Starting from the 7-benzyl-3-chloro-1-hydrazino-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile 6 and 5-hydrazino-6,7,8,9- tetrahydro-3H-pyrazolo[3,4-c]-2,7-naphthyridin-1-amine 12 the 7-benzyl-3-chloro-1-(3,5-dimethyl-1H-pyrazol- 1-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile 7 and 3,5-dimethyl-1H-pyrazol-1-yl-9,11-dimethylpyrimido[1′, 2′: 1,5] pyrazolo[3,4-c]-2,7-naphthyridine 13 were synthesized, via the Knorr synthesis of pyrazoles. Results: The syntheses of 2-benzyl-6,8-diamino-3,4-dihydro-2,7-naphthyridin-1(2H) ones 4 deriving from the rearrangement of compounds 2 and/or 3 were performed. By reaction with benzylamine compound 2a or 3g gave the unexpected formation of N, 7-dibenzyl-8-(benzylimino)-3-pyrrolidin-1-yl-5,6,7,8-tetrahydro-2,7-naphthyridin- 1-amine 5: in fact, the rearrangement was followed by condensation between the C-1 carbonyl group of the 2,7-naphthyridine ring and the benzylamine. Starting from the 7-benzyl-3-chloro-1-(3,5-dimethyl-1H- pyrazol-1-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile 7 the relevant 3-amino-7-benzyl-1-(3,5-dimethyl- 1H-pyrazol-1-yl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitriles 8 were obtained. In harsh experimental conditions the nucleophilic substitution of the 1-pyrazolyl residue took place with formation of 7-benzyl- 1,3-bis[(2-hydroxypropyl) amino]-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile 10. Moreover, compound 7 reacted with hydrazine hydrate giving the pyrazolo[3,4-c]-2,7-naphthyridine 12, which, in turn, furnished a new tetra-heterocyclic system: 3-benzyl-5-(3,5-dimethyl-1H-pyrazol-1-yl)-9,11-dimethyl-1,2,3,4-tetrahydropyrimido[1′, 2′: 1,5] pyrazolo[3,4-c]-2,7-naphthyridine 13. Conclusion: Replacement of methyl group on piperidine ring of 2,7-naphthyridine system with the benzyl one led to new results. Reaction of compound 2a or 3g with benzylamine brought to an unexpected formation of N, 7-dibenzyl-8-(benzylimino)-3-pyrrolidin-1-yl-5,6,7,8-tetrahydro-2,7-naphthyridin-1-amine 5. The reactivity of 7-benzyl-3-chloro-1-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-naphthyridine 7 with nucleophiles was investigated, observing the unexpected substitution of the 1-pyrazolyl residue.

These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 286961-14-6, SDS of cas: 286961-14-6.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem