Tag: M.W:300-400

Electric Literature of 286961-14-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate, SMILES is O=C(N1CCC(B2OC(C)(C)C(C)(C)O2)=CC1)OC(C)(C)C, belongs to naphthyridine compound. In a article, author is Mo, Juan, introduce new discover of the category.

2,2 ‘,4,4 ‘-Tetramethyl-7,7 ‘-diazenediylbis(1,8-naphthyridin-1-ium) bis(perchlorate)

In the title salt, C(20)H(20)N(6)(2+)center dot 2ClO(4)(-), the cation is disposed about a center of symmetry at the mid-point of the N=N bond. The 1,8-naphthyridine systems are planar and the ten atoms have a mean deviation of 0.01 angstrom from the least-squares plane. The two planar 1,8-naphthyridine units are parallel but extend in opposite directions from the diazene bridge. The 1,8-naphthyridine aminium groups interact with perchlorate O atoms through N-H center dot center dot center dot O hydrogen bonds.

Electric Literature of 286961-14-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 286961-14-6.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Electric Literature of 61-19-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 61-19-8, Name is Adenosine 5′-monophosphate, SMILES is O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(O)=O, belongs to naphthyridine compound. In a article, author is Suda, H, introduce new discover of the category.

N,N ‘-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA

We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry. (c) 2005 Elsevier Ltd. All rights reserved.

Electric Literature of 61-19-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 61-19-8.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 298-96-4, Name is Tetrazolium Red, molecular formula is C19H15ClN4. In an article, author is Blanco, MM,once mentioned of 298-96-4, Recommanded Product: Tetrazolium Red.

Mechanistic evidence of a Gabriel Colman-type rearrangement

Rearrangement of quinolinimidoacetic acid derivatives induced by alkoxides leading to a mixture of 7-substituted 8-hydroxy-1,6-naphthyridin-5(6H)-ones and 6-substituted 5-hydroxy-1,7-naphthyridin-8(7H)-ones (Gabriel Colman-type reaction) was studied. Several chemical evidences accounts for a mechanism in two steps with quinolinamic ester intermediates (N-substituted 3-carbamoyl-2-pyridinecarboxylic acid alkyl esters and 2-carbamoyl-3-pyridinecarboxylic acid alkyl esters). These compounds were isolated from a reaction in mild conditions and their structure confirmed through an unequivocal synthesis.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Xing, LY, once mentioned the application of 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C16H28BNO4, molecular weight is 309.2088, MDL number is MFCD03840345, category is naphthyridine. Now introduce a scientific discovery about this category, Recommanded Product: 286961-14-6.

Hydrogen bond directed synthesis of pyridazine and naphthyridine containing macrocycles

This work describes a high-yielding, one-step synthesis of pyrizadine and naphthyridine containing macrocycles directed by intramolecular H-bonding.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 179324-87-9, Name is (R)-BoroLeu-(+)-Pinanediol trifluoroacetate, molecular formula is C17H29BF3NO4. In an article, author is Jin Shou-Wen,once mentioned of 179324-87-9, COA of Formula: C17H29BF3NO4.

Synthesis and structural characterization of di(2-amino-5-methyl-1,8-naphthyridin-1-ium-7-carboxylato)dichlorocuprate(II) dihydrate

Di(2-amino-5-methyl-1,8-naphthyridin-1-ium-7-carboxylato)dichlorocuprate(II) dihydrate has been prepared from 5,7-dimethyl-1,8-naphthyridine-2-amine, CuCl2 center dot 2H(2)O and concentrated hydrochloride acid, and its structure was determined by X-ray diffraction at 298 K. The compound (C20H22Cl2CuN6O6, M-r=576.88) crystallizes in monoclinic, space group P2(1)/n with a=9.102(9), b=12.150(12), c=10.619(10) angstrom, beta=91.20 degrees, V=1174.1(19) angstrom(3), Z=2, D-c=1.632 g/cm(3), F(000)=590, mu=1.208 mm(-1), R=0.0392 and wR=0.0984. The Cu2+ ion is six-coordinated by two nitrogen and two oxygen atoms from two different naphthyridine ligands at the equatorial positions,together with two chloride ions located at the axial positions.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 286961-14-6, Name is tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C16H28BNO4. In an article, author is El-Sayed, Hassan A.,once mentioned of 286961-14-6, HPLC of Formula: C16H28BNO4.

A facile synthesis of highly fluorescent pyrido[2,3-d]pyrimidines and 1,8-naphthyridines via oxazine transformation and enaminic addition reactions

The synthesis and fluorescence properties of highly substituted bicyclic pryridine derivatives are described. 2-Substituted-4-oxo-pyrido[2,3-d]pyrimidines 2-8 resulted from the acylation reaction of alpha-aminonicotinonitrile 1 with aroyl chlorides, diethyl malonate, morpholine-4-carboxylate, acetic anhydride or formic acid under solvent-free conditions. [4+2] Cyclocondensation and cycloaddition reactions of compound type 1 with formamide and ammonium thiocyanate tolerated the fused pyrimidines 9 and 11, respectively. Finally, the Friedlander-like reaction was applied for the synthesis of 1,8-naphthyridines 12-15 via reaction of compound 1 with cyclohexanone, dimedone, acetyl acetone and benzyl methyl ketone, respectively, under AlCl3 catalysis. The fluorescence spectroscopic data of compounds 1-4, 6-8, 11, 12, 14 and 15 measured and significant results were observed.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Related Products of 179324-87-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 179324-87-9, Name is (R)-BoroLeu-(+)-Pinanediol trifluoroacetate, SMILES is CC1(C)[C@@]([H])(C2)C[C@]3([H])[C@](OB([C@H](CC(C)C)N)O3)(C)[C@]12[H].O=C(O)C(F)(F)F, belongs to naphthyridine compound. In a article, author is Chahal, Mandeep K., introduce new discover of the category.

1,8-Naphthyridinic fluorescent ‘turn-on’ and ‘turn-off’ chemosensors for detection of F- and Hg2+ ions mimicking INHIBIT molecular logic behaviour

Two new receptors viz. 2-bromoacetamido-5,7-dimethyl-1,8-naphthyridine (1a) and 2-chloroacetamido-5,7-dimethyl-1,8-naphthyridine (1b) containing 1,8-naphthyridine as fluorophore unit have been designed and synthesised. These receptors exhibited very high selectivity for F- ions among the various anions tested such as H2PO4-, OAc-, Cl-, Br-, I-, HSO4-, PF6-, ClO4-, BF4- and NO3- owing to anion-induced deprotonation of the amide NH by F- ions. Among the various cations tested (Na+, Ag+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ and Mn3+), 1a exhibited selective detection of Hg2+ ions by binding with N1 and N8 atoms of the naphthyridine moiety. Receptor 1a has been explored as a dual-ion detector for F- and Hg2+ ions in two contrasting modes (fluorescence ‘turn-on’ and ‘turn-off’) which is supported by spectroscopic and lifetime measurements. 1a exhibited lower detection limits for F- (0.4 ppm) and Hg2+ (2.4 ppm) ions. These receptors were recovered from anionic species of 1a formed after addition of F- ions by treating with protic solvents such as CH3OH. The mode of binding was also confirmed by spectroscopic and DFT studies. The chemical inputs of F- and Hg2+ ions generate an output which satisfies the condition of two-input INHIBIT logic operators.

Related Products of 179324-87-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 179324-87-9 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, in an article , author is Gencer, Hulya Karaca, once mentioned of 5089-22-5, Formula: C24H14N2O2.

New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors

Owing to the growing need for novel antibacterial agents, we synthesized a novel series of fluoroquinolones including 7-substituted-1-(2,4-difluoropheny1)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid derivatives, which were tested against clinically relevant Gram positive and Gram negative bacteria. Chemical structures of the synthesized compounds were identified using spectroscopic methods. In vitro antimicrobial effects of the compounds were determined via microdilution assay. Microbiological examination revealed that compounds 13 and 14 possess a good antibacterial profile. Compound 14 was the most active and showed an antibacterial profile comparable to that of the reference drugs trovafloxacin, moxifloxacin, and ciprofloxacin. A significant MIC90 value (1.95 mu g/mL) against S. aureus ATCC 25923, E. coli ATCC 35218, and E. coli ATCC 25922 was recorded for compound 14. We observed reduced metabolic activity associated with compounds 13 and 14 in the relevant bacteria via a luminescence ATP assay. Results of this assay supported the antibacterial potency of compounds 13 and 14. An E. coli DNA gyrase inhibitory assay indicated that compound 14 is a potent inhibitor of E. coli DNA gyrase. Docking studies revealed that there is a strong interaction between compound 14 and the E. coli DNA gyrase enzyme. Genotoxicity and cytotoxicity evaluations of compounds 13 and 14 showed that compound 14 is non-genotoxic and less cytotoxic compared to the reference drugs (trovafloxacin, moxifloxacin, and ciprofloxacin), which increases its biological importance. (C) 2017 Elsevier Ltd. All rights reserved.

Interested yet? Read on for other articles about 5089-22-5, you can contact me at any time and look forward to more communication. Formula: C24H14N2O2.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Electric Literature of 3147-75-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 3147-75-9, Name is 2-(2H-Benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol, SMILES is CC(C)(C)CC(C)(C)C1=CC(N2N=C3C=CC=CC3=N2)=C(O)C=C1, belongs to naphthyridine compound. In a article, author is Liao, Bei-Sih, introduce new discover of the category.

An unexpected semi-hydrogenation of a ligand in the complexation of 2,7-bispyridinyl-1,8-naphthyridine with Ru-3(CO)(12)

Thermal reaction of 2,7-bis(2-pyridinyl)-l, 8-naphthyridine (bpnp) with Ru-3(CO)(12) in the presence of moisture resulted in the formation of a formate-bridged diruthenium complex [(bpnp-H-3)Ru-2(mu-HCOO)(CO)(4)] (1), in which the ligand was partially hydrogenated. Complex 1 was fully characterized by spectroscopic analyses and X-ray single crystal determination. Regarding the partially reduced ligand in 1, it occurs through a water-gas shift type reduction. The bridging formate ligand can be substituted by other carboxylate ligands. Physical and chemical properties of the newly prepared complexes were investigated.

Electric Literature of 3147-75-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3147-75-9 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Application of 5089-22-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, SMILES is C1(C2=NC3=CC=CC=C3O2)=C4C=CC=CC4=C(C5=NC6=CC=CC=C6O5)C=C1, belongs to naphthyridine compound. In a article, author is Pascali, Giancarlo, introduce new discover of the category.

Preliminary Investigation of a Novel F-18 Radiopharmaceutical for Imaging CB2 Receptors in a SOD Mouse Model

We successfully radiolabelled a novel prospective cannabinoid type 2 receptor ligand with F-18 and tested its biodistribution in animal models by positron emission tomography (PET)/computed tomography (CT) imaging. The radiolabelling process was conducted on an alkyl mesylate fragment of the main naphthyridine core, using highly efficient microfluidic technology. No preliminary protection was needed, and the product was purified by semi-prep HPLC and SPE formulation, allowing the desired diastereomeric mixture to be obtained in 29% radiochemical yield and >95% radiochemically pure. SOD1(G93A) mice were used as model of overexpression of CB2 receptors; PET imaging revealed a significant increase of the tracer distribution volume in the brain of symptomatic subjects compared with the asymptomatic ones.

Application of 5089-22-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5089-22-5 is helpful to your research.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem