As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO113,mainly used in chemical industry, its synthesis route is as follows.,254-79-5
[000712j To a solution of Compound 90A (1.0 g, 7.69 mol) in acetic acid (8 mL) was added NaOAc (1 .26 g, 15.38 mmol) and a solution of bromine (0.43 mL, 8.46 mmol) in acetic acid (2 mL) at 85 C. The mixture was stirred at 85 C for four hours, cooled to room temperature, and filtered. The filtrate was concentrated under vacuum and the residue was purified with flash column chromatography on silica gel (petroleum in ethyl acetate, 30% v/v) to render Compound 90B. LC-MS (ESI) mlz: 209 [M+H] ?H-NMR (CDC13, 400 MHz) 5 (ppm) 7.70 (dd, J= 4.0, 8.8 Hz, 1H), 8.43 (d, J= 8.4 Hz, 1H), 8.63 (d, J 2.4 Hz, 1H), 7.45 (t,J=2.4Hz, 1H).
With the complex challenges of chemical substances, we look forward to future research findings about 1,5-Naphthyridine,belong naphthyridine compound
Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; WO2015/65937; (2015); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem