Tag: M.W:100-200

249889-68-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 8-Chloro-2-methoxy-1,5-naphthyridine, cas is 249889-68-7,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.

The 2-[2-methoxy-4-(6-methoxy-l55~naphthyridm-4-yloxy)phenyl]acetic acid used as a5 starting material was prepared as follows :; -Under an atmosphere of argon, a mixture of 4-chloro-6-methoxy-l,5-naphthyridine (0.97 g), tert-bvLtyl 2-(4-hydroxy-2-methoxyphenyl)acetate (1.19 g), caesium carbonate (3.26 g) and DMF (10 ml) was stirred and heated to 13O0C for 3.5 hours. The resultant mixture was cooled to ambient temperature and partitioned between ethyl acetate and water.I0 The organic phase was dried over magnesium sulphate and evaporated. The residue was purified by column chromatography on silica using increasingly polar mixtures of petroleum ether and ethyl acetate as eluent. There was thus obtained tert-bxxtyl 2-[2-methoxy- 4-(6-methoxy-l,5-naphthyridin-4-yloxy)phenyl]acetate (1.22 g); 1H NMR Spectrum: (DMSOd6) 1.41 (s, 9H)5 3.51 (s, 2H), 3.75 (s, 3H)5 3.94 (s, 3H)5 6.71 (m5 IH), 6.92 (m, 2H)5 is 7.24 (d5 IH)5 7.29 (d, IH)5 8.27 (d5 IH)5 8.61 (d, IH).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 8-Chloro-2-methoxy-1,5-naphthyridine, 249889-68-7

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113548; (2007); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 1,6-Naphthyridine-2-carboxylic acid, and cas is 197507-59-8, its synthesis route is as follows.

Triethylamine (3.03 ml, 21.8 mmol), ethyl chloroformate (3.73 ml, 39.0 mmol) and 4-dimethylaminopyridine (DMAP) (2.40 g, 19.6 mmol) are added, at O0C, to a solution of l,6-naphthyridine-2-carboxylic acid (138) (Chan, L., Jin, H., Stefanac, T., Lavallee, J.F., Falardeau, G., Wang, W., Bedard, J., May, S. and Yuen, L., J. Med. Chem., 1999, 42, 3023-3025) (1.00 g, 5.75 mmol) in anhydrous dichloromethane (75 ml). After returning to ambient temperature, the reaction mixture is brought to reflux for 5 hours, the solution is evaporated to dryness and then the residue is purified on a column of alumina eluted with ethyl acetate to result in the ester 139 (517 mg, 2.56 mmol). Yield: 45%; Rf: 0.86 (Al2O3, ethyl acetate); melting point: 106-1080C; 1H NMR (400 MHz, CDCl3) d 1.41 (t, 3H, J = 7 Hz), 4.49 (q, 2H, J= 7 Hz), 8.02 (d, IH, J= 6 Hz), 8.21 (d, IH, J= 8.5 Hz), 8.39 (d, IH, J = 8.5 Hz), 8.75 (d, IH, J = 6 Hz), 9.29 (s, IH); 13C NMR (100 MHz, CDCl3) d 14.3, 62.0, 122.4, 122.7, 124.0, 137.2, 147.5, 149.7, 152.3, 152.9, 164.6; IR (KBr) V cm”1 : 1256, 1734; MS (m/z, %) 202 (M+, 3), 158 (18), 130 (100), 102 (15), 75 (22), 51 (16).

197507-59-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,197507-59-8 ,1,6-Naphthyridine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); WO2008/12782; (2008); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 8-Chloro-3-methoxy-1,5-naphthyridine, and cas is 952059-69-7, its synthesis route is as follows.

Example 37 (Method Cl); Synthesis of N-(4-(7-methoxy-l ,5-naphthyridin-4-yloxy)phenyl)-4-(4- methoxyphenyl)phthalazin-l-amineA 5 mL microwave tube was charged with 4-(4-(4-methoxyphenyl)phthalazin-l- ylamino)phenol and 3 equivalents of cesium carbonate (342 mg, 1.048 mmol) in 1.8 mL of DMF. The mixture was stirred at RT for 10 min. Following addition of 8-chloro-3- methoxy-l,5-naphthyridine (88 mg, 0.454 mmol), the vessel was capped and irradiated at 150 0C for 15 min in the microwave, at which time the reaction was determined complete by LC/MS. The mixture was cooled to ambient temperature and diluted with water. The solids were filtered and washed with water. The solids were triturated with methanol, filtered to remove remaining impurities, washed with additional methanol and dried under vacuum to afford N-(4-(7-methoxy- 1 ,5-naphthyridin-4-yloxy)phenyl)-4-(4- methoxyphenyl)phthalazin-l -amine as a light orange solid. MS [M+H]=502; Calc’d 501.54 for C30H25N5O3.

952059-69-7, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,952059-69-7 ,8-Chloro-3-methoxy-1,5-naphthyridine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; AMGEN INC.; WO2008/124083; (2008); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 2-Chloro-1,5-naphthyridine, and cas is 7689-62-5, its synthesis route is as follows.

A solution of the compound 0001-2 (2.88 g) and sodium acetate (2.89 g) in acetic acid (15 mL) was stirred at 85C for 5 minutes. A solution of bromine (0.99 mL) in acetic acid (2.5 mL) was dropwise added thereto. Further acetic acid (2 mL) was added dropwise thereto, and the mixture was stirred at 85C for 3 hours. To a 6 M aqueous sodium hydroxide solution (60 mL) under stirring with ice-cooling, the reaction solution which had been cooled to room temperature was added dropwise. The precipitated solid was separated by filtration, and the solid was then suspended in methanol (5 mL), and thereafter subjected to sonication. Thereafter, the suspension was filtered, and then the resulting solid was washed with methanol (3 mL). The obtained solid was suspended in a 75 v/v% aqueous methanol solution (8 mL), subjected to sonication, and then the suspension was filtered, and the residue was then washed with a 75 v/v% aqueous methanol solution twice to obtain a compound 0001-3 (3.33 g) as a pale yellow solid. 1H-NMR (DMSO-d6) delta: 9.13 (1H, d), 8.77 (1H, dd), 8.53 (1H, dd), 7.91 (1H, d). MS m/z (M+H): 245.

7689-62-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,7689-62-5 ,2-Chloro-1,5-naphthyridine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; FURUYA, Kentarou; TERAO, Takahiro; SEKINE, Shinichirou; NAKAGAWA, Daisuke; EP2727920; (2014); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

Name is 8-Chloro-3-methoxy-1,5-naphthyridine, as a common heterocyclic compound, it belongs to naphthyridine compound, and cas is 952059-69-7, its synthesis route is as follows.

2-(2-((7-Methoxy-l,5-naphthyridin-4-yl)(methyl)amino)ethyl)-6-(4- methylthiophen-2-yl)pyridazin-3(2H)-one. A suspension of 2-(2- (methylamino)ethyl)-6-(4-methylthiophen-2-yl)pyridazin-3(2H)-one (275 mg, 1103 mumol) and 8-chloro-3-methoxy-l,5-naphthyridine (193 mg, 993 mumol) in iPrOH (5 mL) was heated to 100 C for 18 h in an appropriately sealed vial. The mixture was partitioned between CH2Cl2 (30 mL) and IM NaOH (10 mL), and the organic dried over MgSO4. After concentration under reduced pressure, the organic residue was dissolved in iPrOH (2 mL) and the rsulting crystalized solid was washed with iPrOH (2x 0.5 mL) then dried under reduced pressure. MS (ESI pos. ion) m/z (MH+): 408. Calc’d exact mass for C2ieta2iN5O2S: 407. 1H NMR (400 MHz, Chloroform-d) delta ppm 2.26 (s, 3 H) 3.22 (s, 3 H) 3.83 (s, 3 H) 4.51 (t, J=5.77 Hz, 2 H) 4.75 (t, J=5.77 Hz, 2 H) 6.55 (d, J=5.52 Hz, 1 H) 6.60 (d, J=9.54 Hz, 1 H) 6.91 (s, 1 H) 6.97 (s, 1 H) 7.19 (d, J=9.54 Hz, 1 H) 7.32 (d, J=3.01 Hz, 1 H) 8.32 (d, J=5.52 Hz, 1 H) 8.46 (d, J=2.51 Hz, 1 H).

952059-69-7, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,952059-69-7 ,8-Chloro-3-methoxy-1,5-naphthyridine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; AMGEN INC.; WO2008/103277; (2008); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

15936-10-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2-Chloro-1,8-naphthyridine, cas is 15936-10-4,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 2 Preparation of 2-(4-(1,8-naphthyridin-2-yloxy)phenoxy)propanoic acid STR9 A 3-necked flask was equipped with a thermometer, a magnetic stirrer, a reflux condenser and a nitrogen line and flushed with nitrogen. The flask was charged with 15 ml of hexane and 1.38 gm (28.8 m moles) of 50% NaH/oil dispersion. After stirring for 10 minutes the hexane was decanted and replaced with 5 ml of DMSO followed by the dropwise addition of a solution of 2.18 gm (12 m moles) of 2-(4-hydroxyphenoxy)propanoic acid in 5 ml of DMSO. The mixture was warmed to 60 C. and a solution of 1.97 gm of 2-chloro-1,8-naphthyridine in 10 ml of DMSO was added. After warming the reaction mixture at 95 C. for one hour, the mixture was cooled to room temperature and water cautiously added. The solution was extracted with methylene chloride and the aqueous phase neutralized with acetic acid to give a white precipitate. The aqueous mixture was extracted with CH2 Cl2 and the organic layer washed twice with water, dried over Na2 SO4 and evaporated to dryness to give 3.3 gm of yellow solid which could not be redissolved in ether or CH2 Cl2.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Chloro-1,8-naphthyridine, 15936-10-4

Reference£º
Patent; The Dow Chemical Company; US4472193; (1984); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

254-60-4, Name is 1,8-Diazanaphthalene, belongs to naphthyridine compound, is a common compound. Computed Properties of C8H6N2In an article, once mentioned the new application about 254-60-4.

N-doped carbon material is a promising alternative to mercury catalyst for acetylene hydrochlorination. Herein, we present an innovative strategy to synthesize pyridinic N-rich aromatic ladder structure material through controlling the self-assembly of polyacrylonitrile polymer chains. The prepared material gave ?93% conversion of acetylene with >99% selectivity for vinyl chloride and exhibited a satisfying stability during 200 h lifetime test. Characterizations and density functional theory calculations demonstrated that the activity of the catalyst likely originates from three types of active pyridinic N sites in the ladder structure. Particularly, the pyridinic N sites with one H atom nearby are more active because the H atom can stabilize the transition state through H¡¤¡¤¡¤Cl bond, thereby reducing the energy barrier. The energy barriers on these pyridinic N sites were calculated to be 29.8 and 47.4 kcal mol-1, much lower than 83.2 and 84.4 kcal mol-1 on those sites without H atom nearby. The facile and highly effective strategy for the synthesis of a specific N species with defined formation mechanism is expected to be helpful in the design of other green catalysts for acetylene hydrochlorination.

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1,233-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N227 – PubChem

Reference of 254-60-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 254-60-4, 1,8-Diazanaphthalene, introducing its new discovery.

A novel and easily synthesized compound, N-(2-(2-benzothiazol-2-yl)vinyl-4-methyl-1,8- naphthyrine-7-yl)acetamide (1) based on naphthyridine and benzothiazole group, has been developed as a turn-on fluorescent chemosensor for Al3+ and Fe3+ simultaneously. The absorbance and fluorescent intensities of 1 increased linearly in aqueous solution upon the interaction of 1 with Al3+ or Fe3+. The other co-existing metal ions have no obvious effect on the detection. The Job’s plot and the ESI mass spectra indicated the formation of 1:1 complex between 1 and Al3+or Fe3+. The sensing mechanism was proposed according to the Job’s plot, ESI mass spectra, 1H NMR spectra?and density functional theory (DFT) calculation. The properties of the model compound N-(2-((2-methylbenzothiazol-6-ylimino)methyl)-4-methyl-1,8-naphthyridin-7-yl)acetamide (2), which was designed and synthesized in order to prove the sensing mechanism, also verified the proposed sensing mechanism.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 254-60-4. In my other articles, you can also check out more blogs about 254-60-4

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1,292-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N286 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C8H6N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2

The adducts WOF4.napy and WOF4.dmnapy were prepared from the reaction of WOF4 with 1,8-naphthyridine (napy) and 2,7-dimethyl-1,8-naphthyridine (dmnapy) in dichloromethane.Both adducts were characterized by elemental analysis, X-Ray powder data and infrared absorption spectroscopy.Their solubility in the usual organic solvents was found to be negligible and the trace amounts of species present in the solutions were identified as ionic derivatives originating from sidereactions.

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1,47-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N41 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 2-Chloro-1,8-naphthyridine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 15936-10-4, name is 2-Chloro-1,8-naphthyridine. In an article£¬Which mentioned a new discovery about 15936-10-4

AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge

Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington’s Disease, and the like

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 15936-10-4, help many people in the next few years.Quality Control of 2-Chloro-1,8-naphthyridine

Reference£º
1,474-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N468 – PubChem